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Literature summary extracted from

  • Pernas, M.; Sanchez-Ramos, I.; Sanchez-Monge, R.; Lombardero, M.; Arteaga, C.; Castanera, P.; Salcedo, G.
    Der p 1 and Der f 1, the highly related and major allergens from house dust mites, are differentially affected by a plant cystatin (2000), Clin. Exp. Allergy, 30, 972-978.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.65 chestnut cystatin inhibits the enzyme and greatly increases the larval mortality Dermatophagoides farinae
3.4.22.65 E-64
-
 Dermatophagoides farinae
3.4.22.65 E-64
-
 Dermatophagoides pteronyssinus
3.4.22.65 egg-white cystatin
-
 Dermatophagoides farinae
3.4.22.65 additional information Der f1 from Dermatophagoides farinae is highly susceptible, Der p 1 from Dermatophagoides pteronyssinus is not affected by chestnut cystatin. Der p 1 inactivates chestnut chystatin by a specific proteolytic cleavage between Gly6 and Val7 Dermatophagoides pteronyssinus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.22.65 0.017
-
 casein pH 6.5, 37°C Dermatophagoides pteronyssinus
3.4.22.65 0.033
-
 casein pH 6.5, 30°C Dermatophagoides farinae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.65 additional information Dermatophagoides farinae allergen from Dermatophagoides farinae ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.65 Dermatophagoides farinae
-
-
-
3.4.22.65 Dermatophagoides pteronyssinus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.65 azocasein + H2O
-
 Dermatophagoides pteronyssinus ?
-
 ?
3.4.22.65 casein + H2O
-
 Dermatophagoides farinae ?
-
 ?
3.4.22.65 casein + H2O
-
 Dermatophagoides pteronyssinus ?
-
 ?
3.4.22.65 chestnut cystatin + H2O specific proteolytic cleavage between Gly6 and Val7, giving rise to a noninhibitory processed protein. Not cleaved by Der f 1 from Dermatophygoides farinae Dermatophagoides pteronyssinus ?
-
 ?
3.4.22.65 additional information allergen from Dermatophagoides farinae Dermatophagoides farinae ?
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.22.65 0.000031
-
 chestnut cystatin pH 6.5, 30°C Dermatophagoides farinae