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Literature summary extracted from

  • Kapadia, C.; Chang, A.; Sotiropoulou, G.; Yousef, G.M.; Grass, L.; Soosaipillai, A.; Xing, X.; Howarth, D.H.; Diamandis, E.P.
    Human kallikrein 13: production and purification of recombinant protein and monoclonal and polyclonal antibodies, and development of a sensitive and specific immunofluorometric assay (2003), Clin. Chem., 49, 77-86.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.119 expression in Pichia pastoris Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.119 cytosol
-
 Homo sapiens 5829
-
3.4.21.119 extracellular enzyme is also secreted into biological fluids Homo sapiens
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.119 30000
-
 secreted enzyme, gel filtration Homo sapiens
3.4.21.119 50000
-
 x * 50000, recombinant glycosylated enzyme, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.119 polypeptide + H2O Homo sapiens
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.119 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.119 glycoprotein enzyme is highly glycosylated Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.119 recombinant enzyme from Pichia pastoris Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.21.119 Hydrolyses mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg-/- pair in the N-terminus, to yield mature renin enzyme is a serine protease Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.119 amniotic fluid
-
 Homo sapiens
-
3.4.21.119 ascites fluid from women with advanced ovarian carcinoma Homo sapiens
-
3.4.21.119 breast
-
 Homo sapiens
-
3.4.21.119 cerebrospinal fluid traces Homo sapiens
-
3.4.21.119 esophagus highest activity in esophagus and tonsil Homo sapiens
-
3.4.21.119 kidney
-
 Homo sapiens
-
3.4.21.119 lung
-
 Homo sapiens
-
3.4.21.119 milk
-
 Homo sapiens
-
3.4.21.119 additional information fetal tissue pattern is similar to the adult one Homo sapiens
-
3.4.21.119 ovarian follicle
-
 Homo sapiens
-
3.4.21.119 prostate
-
 Homo sapiens
-
3.4.21.119 salivary gland
-
 Homo sapiens
-
3.4.21.119 seminal plasma
-
 Homo sapiens
-
3.4.21.119 skin
-
 Homo sapiens
-
3.4.21.119 testis
-
 Homo sapiens
-
3.4.21.119 thyroid gland
-
 Homo sapiens
-
3.4.21.119 tonsil highest activity in esophagus and tonsil Homo sapiens
-
3.4.21.119 trachea
-
 Homo sapiens
-
3.4.21.119 ureter
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.119 FSR-amido-4-methylcoumarin + H2O fluorogenic trypsin-like peptide substrate Homo sapiens FSR + 7-amino-4-methylcoumarin
-
 ?
3.4.21.119 polypeptide + H2O
-
 Homo sapiens peptides
-
 ?
3.4.21.119 VPR-amido-4-methylcoumarin + H2O fluorogenic trypsin-like peptide substrate Homo sapiens VPR + 7-amino-4-methylcoumarin
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.119 ? x * 50000, recombinant glycosylated enzyme, SDS-PAGE Homo sapiens
3.4.21.119 ? x * 25000-28000, recombinant deglycosylated enzyme, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.21.119 K13
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.119 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.119 7.5
-
 assay at Homo sapiens