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Literature summary extracted from

  • Yousef, G.M.; Scorilas, A.; Magklara, A.; Soosaipillai, A.; Diamandis, E.P.
    The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family - genomic characterization, mapping, tissue expression and hormonal regulation (2000), Gene, 254, 119-128.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.117 additional information estrogen and glucocorticoids cause up-regulation of gene expression Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.117 DNA sequence determination and analysis, gene KLK7 mapps to chromosomal locus 19q13.3-13.4, human kallikrein gene family locus Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.117 additional information Homo sapiens enzyme is regulated by steroid hormones ?
-
 ?
3.4.21.117 polypeptide + H2O Homo sapiens
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.117 Homo sapiens P49862 gene KLK7 or PRSS6, genomic sequence
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.117 brain
-
 Homo sapiens
-
3.4.21.117 cerebellum
-
 Homo sapiens
-
3.4.21.117 kidney
-
 Homo sapiens
-
3.4.21.117 mammary gland
-
 Homo sapiens
-
3.4.21.117 additional information no expression in liver, pancreas, small intestine, bone marrow, ovary, skeletal muscle, spleen, colon, adrenal gland, prostate, heart, lung, and stomach Homo sapiens
-
3.4.21.117 placenta low content Homo sapiens
-
3.4.21.117 salivary gland low content Homo sapiens
-
3.4.21.117 skin
-
 Homo sapiens
-
3.4.21.117 spinal cord
-
 Homo sapiens
-
3.4.21.117 stratum corneum
-
 Homo sapiens
-
3.4.21.117 testis low content Homo sapiens
-
3.4.21.117 thymus low content Homo sapiens
-
3.4.21.117 thyroid gland low content Homo sapiens
-
3.4.21.117 trachea low content Homo sapiens
-
3.4.21.117 uterus low content Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.117 additional information enzyme is regulated by steroid hormones Homo sapiens ?
-
 ?
3.4.21.117 polypeptide + H2O
-
 Homo sapiens peptides
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.117 SCCE
-
 Homo sapiens