EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.117 | alpha1-Aantichymotrypsin | 99.6% inhibition at 0.00015 mM | Homo sapiens | |
3.4.21.117 | alpha1-Macroglobulin | 44.2% inhibition at 0.00015 mM | Homo sapiens | |
3.4.21.117 | Alpha1-proteinase inhibitor | 89.6% inhibition at 0.00015 mM | Homo sapiens | |
3.4.21.117 | antileukoprotease | 88.8% inhibition at 0.0022 mM | Homo sapiens | |
3.4.21.117 | Aprotinin | 90.3% inhibition at 0.0027 mM | Homo sapiens | |
3.4.21.117 | Eglin c | 99.8% inhibition at 0.00015 mM | Homo sapiens | |
3.4.21.117 | elafin | 33.4% inhibition at 0.0015 mM | Homo sapiens | |
3.4.21.117 | additional information | inhibition assay: 15 min preincubation of the enzyme with inhibitor at 21°C; no inhibition by Mg2+, E-64, 1,10-phenanthrolin, EDTA | Homo sapiens | |
3.4.21.117 | pepstatin A | weak inhibition, 23.6% inhibition at 0.1 mM | Homo sapiens | |
3.4.21.117 | Soybean trypsin inhibitor | 99.6% inhibition at 0.00015 mM | Homo sapiens | |
3.4.21.117 | Zn2+ | 92.6% inhibition at 0.1 mM | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.21.117 | additional information | - |
additional information | - |
Homo sapiens | |
3.4.21.117 | 0.08 | - |
acetyl-Phe-Val-Arg-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
3.4.21.117 | 0.22 | - |
succinyl-Phe-Leu-Phe-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
3.4.21.117 | 0.65 | - |
methoxy-succinyl-Arg-Pro-Tyr-4-nitroanilide | pH 8.0, 37°C | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.117 | polypeptide + H2O | Homo sapiens | - |
peptides | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.117 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.4.21.117 | - |
Homo sapiens |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
3.4.21.117 | cleavage of proteins with aromatic side chains in the P1 position | enzyme is a chymotrypsin-like serine protease | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.21.117 | stratum corneum | plantar | Homo sapiens | - |
3.4.21.117 | stratum corneum | from heels | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.117 | acetyl-Phe-Val-Arg-4-nitroanilide + H2O | chromogenic substrate | Homo sapiens | acetyl-Phe-Val-Arg + 4-nitroaniline | - |
? | |
3.4.21.117 | D-Ile-Pro-Arg-4-nitroanilide + H2O | chromogenic substrate | Homo sapiens | D-Ile-Pro-Arg + 4-nitroaniline | - |
? | |
3.4.21.117 | D-Ile-Pro-Arg-4-nitroanilide + H2O | low activity | Homo sapiens | D-Ile-Pro-Arg + 4-nitroaniline | - |
? | |
3.4.21.117 | D-Ile-Pro-Arg-4-nitroanilide + H2O | i.e. S2288 | Homo sapiens | D-Ile-Pro-Arg + 4-nitroaniline | - |
? | |
3.4.21.117 | methoxy-succinyl-Ala-Ala-Pro-Met-4-nitroanilide + H2O | chromogenic substrate | Homo sapiens | methoxy-succinyl-Ala-Ala-Pro-Met + 4-nitroaniline | - |
? | |
3.4.21.117 | methoxy-succinyl-Ala-Ala-Pro-Met-4-nitroanilide + H2O | low activity | Homo sapiens | methoxy-succinyl-Ala-Ala-Pro-Met + 4-nitroaniline | - |
? | |
3.4.21.117 | methoxy-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O | chromogenic substrate | Homo sapiens | methoxy-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline | - |
? | |
3.4.21.117 | methoxy-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O | low activity | Homo sapiens | methoxy-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline | - |
? | |
3.4.21.117 | methoxy-succinyl-Arg-Pro-Tyr-4-nitroanilide + H2O | best substrate | Homo sapiens | methoxy-succinyl-Arg-Pro-Tyr + 4-nitroaniline | - |
? | |
3.4.21.117 | methoxy-succinyl-Arg-Pro-Tyr-4-nitroanilide + H2O | chromogenic substrate | Homo sapiens | methoxy-succinyl-Arg-Pro-Tyr + 4-nitroaniline | - |
? | |
3.4.21.117 | methoxy-succinyl-Arg-Pro-Tyr-4-nitroanilide + H2O | i.e. S2586 | Homo sapiens | methoxy-succinyl-Arg-Pro-Tyr + 4-nitroaniline | - |
? | |
3.4.21.117 | N-carbobenzoxy-Gly-Pro-Arg-4-nitroanilide + H2O | chromogenic substrate | Homo sapiens | N-carbobenzoxy-Gly-Pro-Arg + 4-nitroaniline | - |
? | |
3.4.21.117 | N-carbobenzoxy-Gly-Pro-Arg-4-nitroanilide + H2O | low activity | Homo sapiens | N-carbobenzoxy-Gly-Pro-Arg + 4-nitroaniline | - |
? | |
3.4.21.117 | N-carbobenzoxy-Val-Gly-Arg-4-nitroanilide + H2O | chromogenic substrate | Homo sapiens | N-carbobenzoxy-Val-Gly-Arg + 4-nitroaniline | - |
? | |
3.4.21.117 | N-carbobenzoxy-Val-Gly-Arg-4-nitroanilide + H2O | low activity | Homo sapiens | N-carbobenzoxy-Val-Gly-Arg + 4-nitroaniline | - |
? | |
3.4.21.117 | polypeptide + H2O | - |
Homo sapiens | peptides | - |
? | |
3.4.21.117 | succinyl-Phe-Leu-Phe-4-nitroanilide + H2O | chromogenic substrate | Homo sapiens | succinyl-Phe-Leu-Phe + 4-nitroaniline | - |
? | |
3.4.21.117 | succinyl-Phe-Leu-Phe-4-nitroanilide + H2O | low activity | Homo sapiens | succinyl-Phe-Leu-Phe + 4-nitroaniline | - |
? | |
3.4.21.117 | succinyl-Val-Pro-Phe-4-nitroanilide + H2O | chromogenic substrate | Homo sapiens | succinyl-Val-Pro-Phe + 4-nitroaniline | - |
? | |
3.4.21.117 | succinyl-Val-Pro-Phe-4-nitroanilide + H2O | low activity | Homo sapiens | succinyl-Val-Pro-Phe + 4-nitroaniline | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.21.117 | SCCE | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.4.21.117 | 37 | - |
assay at | Homo sapiens |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.21.117 | additional information | - |
additional information | - |
Homo sapiens | |
3.4.21.117 | 0.04 | - |
acetyl-Phe-Val-Arg-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
3.4.21.117 | 0.05 | - |
succinyl-Phe-Leu-Phe-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
3.4.21.117 | 1.2 | - |
methoxy-succinyl-Arg-Pro-Tyr-4-nitroanilide | pH 8.0, 37°C | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.21.117 | 8 | - |
assay at | Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.21.117 | 0.00000033 | - |
Eglin c | pH 8.0, 37°C | Homo sapiens | |
3.4.21.117 | 0.000027 | - |
Aprotinin | pH 8.0, 37°C | Homo sapiens | |
3.4.21.117 | 0.000063 | - |
antileukoprotease | pH 8.0, 37°C | Homo sapiens | |
3.4.21.117 | 0.0016 | - |
elafin | pH 8.0, 37°C | Homo sapiens |