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Literature summary extracted from
- Isolation and characterization of pteroylpolyglutamate hydrolase from rat intestinal mucosa (1984), J. Biol. Chem., 259, 6364-6368.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.19.9 | Dextran sulfate | - |
Rattus norvegicus | |
| 3.4.19.9 | heparin | - |
Rattus norvegicus |  |
| 3.4.19.9 | p-hydroxymercuribenzoate | - |
Rattus norvegicus | |
| 3.4.19.9 | poly-gamma-glutamic acid | - |
Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.19.9 | 0.00021 | - |
Pteroylheptaglutamate | - |
Rattus norvegicus | |
| 3.4.19.9 | 0.00067 | - |
Pteroyltriglutamate | - |
Rattus norvegicus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.19.9 | 80000 | - |
gel filtration | Rattus norvegicus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.19.9 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.19.9 | affinity chromatography | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.19.9 | intestine | mucosa | Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.4.19.9 | additional information | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.19.9 | polyglutamylfolate + H2O | endopeptidase-like mode of action | Rattus norvegicus | ? | - |
? | |
| 3.4.19.9 | pteroylheptaglutamate + H2O | - |
Rattus norvegicus | ? | pteroylmonoglutamate + hexaglutamyl peptide | ? | |
| 3.4.19.9 | pteroyltriglutamate + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.19.9 | pteroyltriglutamate + H2O | - |
Rattus norvegicus | pteroylglutamate + glutamate | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.19.9 | 4.5 | - |
- |
Rattus norvegicus |
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