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Literature summary extracted from
- Studies on the enzymatic hydrolysis of polyglutamyl folates by chicken liver folyl poly-gamma-glutamyl carboxypeptidase. I. Intracellular localization, purification and partial characterization of the enzyme (1977), Biochim. Biophys. Acta, 481, 594-607.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.19.9 | 2-mercaptoethanol | stimulates | Gallus gallus |  |
| 3.4.19.9 | Urea | low concentrations stimulate | Gallus gallus | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.19.9 | citrate | - |
Gallus gallus | |
| 3.4.19.9 | PCMB | - |
Gallus gallus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.19.9 | 0.00083 | - |
N5-methyltetrahydropteroyltetraglutamate | - |
Gallus gallus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.19.9 | lysosome | - |
Gallus gallus | 5764 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.19.9 | Mn2+ | stimulates | Gallus gallus | |
| 3.4.19.9 | Na+ | stimulates | Gallus gallus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.19.9 | 57500 | - |
gel filtration | Gallus gallus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.19.9 | Gallus gallus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.19.9 | - |
Gallus gallus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.19.9 | liver | - |
Gallus gallus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.4.19.9 | additional information | - |
- |
Gallus gallus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.19.9 | N5-methyltetrahydropteroyltetraglutamate + H2O | cleaves the terminal gamma-glutamyl residues, finally releasing a monoglutamyl end-product | Gallus gallus | ? | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.19.9 | 35 | - |
- |
Gallus gallus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.19.9 | 4.1 | - |
2 pH-optima: pH 4.1 and pH 5.2 | Gallus gallus |
| 3.4.19.9 | 5.2 | - |
2 pH-optima: pH 4.1 and pH 5.2 | Gallus gallus |
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Release 2023.1 (January 2023)
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