Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Sugiura, M.; Ito, Y.; Hirano, K.; Sawaki, S.
    Purification and properties of human kidney dipeptidases (1978), Biochim. Biophys. Acta, 522, 541-550.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.13.19 1,10-phenanthroline
-
 Homo sapiens
3.4.13.19 Co2+
-
 Homo sapiens
3.4.13.19 cysteine
-
 Homo sapiens
3.4.13.19 EDTA
-
 Homo sapiens
3.4.13.19 N-bromosuccinimide
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.13.19 0.056
-
 L-Leu-L-Leu enzyme form F Homo sapiens
3.4.13.19 0.086
-
 L-Leu-L-Leu enzyme form S Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.13.19 Cd2+ 1 mM, activates Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.13.19 66000
-
 2 * 66000, enzyme form F, SDS-PAGE Homo sapiens
3.4.13.19 94000
-
 1 * 94000 + 1 * 115000, enzyme form S, SDS-PAGE Homo sapiens
3.4.13.19 115000
-
 1 * 94000 + 1 * 115000, enzyme form S, SDS-PAGE Homo sapiens
3.4.13.19 135000
-
 enzyme form F, gel filtration Homo sapiens
3.4.13.19 200000
-
 enzyme form S, gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.13.19 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.13.19 glycoprotein
-
 Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.13.19 2 forms different in electrophoretic mobility: form S (slow) and F (fast) Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.13.19 kidney
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.13.19 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.13.19 Ala-Ala + H2O
-
 Homo sapiens Ala + Ala
-
 ?
3.4.13.19 Gly-Gly + H2O
-
 Homo sapiens Gly + Gly
-
 ?
3.4.13.19 Gly-Leu + H2O
-
 Homo sapiens Gly + Leu
-
 ?
3.4.13.19 L-Leu-L-Leu + H2O
-
 Homo sapiens L-Leu + L-Leu
-
 ?
3.4.13.19 Leu-Gly + H2O
-
 Homo sapiens Leu + Gly
-
 ?
3.4.13.19 Met-Met + H2O
-
 Homo sapiens Met + Met
-
 ?
3.4.13.19 Phe-Tyr + H2O
-
 Homo sapiens Phe + Tyr
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.13.19 dimer 1 * 94000 + 1 * 115000, enzyme form S, SDS-PAGE Homo sapiens
3.4.13.19 dimer 2 * 66000, enzyme form F, SDS-PAGE Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.13.19 40
-
 enzyme form S Homo sapiens
3.4.13.19 70
-
 enzyme form F Homo sapiens

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.4.13.19 40
-
 enzyme form S is unstable above Homo sapiens
3.4.13.19 60
-
 enzyme form F is stable up to Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.13.19 9
-
 enzyme form F Homo sapiens
3.4.13.19 9 11 enzyme form S Homo sapiens

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
3.4.13.19 6
-
 unstable below, both enzyme forms Homo sapiens
3.4.13.19 8
-
 both enzyme forms stable Homo sapiens

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.4.13.19 Homo sapiens
-
 4.8 4.7