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Literature summary extracted from

  • Brock, T.G.; Maydanski, E.; McNish, R.W.; Peters-Golden, M.
    Co-localization of leukotriene A4 hydrolase with 5-lipoxygenase in nuclei of alveolar macrophages and rat basophilic leukemia cells but not neutrophils (2001), J. Biol. Chem., 276, 35071-35077.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.3.2.6 medicine the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.3.2.6 cytoplasm
-
 Rattus norvegicus 5737
-
3.3.2.6 cytosol
-
 Rattus norvegicus 5829
-
3.3.2.6 additional information the subcellular distribution is cellspecific Rattus norvegicus
-
-
3.3.2.6 nucleoplasm
-
 Rattus norvegicus 5654
-
3.3.2.6 nucleus
-
 Rattus norvegicus 5634
-
3.3.2.6 soluble
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O Rattus norvegicus biosynthesis of leukotriene B4 leukotriene B4
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.6 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.6 lung
-
 Rattus norvegicus
-
3.3.2.6 macrophage alveolar macrophage Rattus norvegicus
-
3.3.2.6 neutrophil
-
 Rattus norvegicus
-
3.3.2.6 RBL-1 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O
-
 Rattus norvegicus leukotriene B4
-
 ?
3.3.2.6 leukotriene A4 + H2O biosynthesis of leukotriene B4 Rattus norvegicus leukotriene B4
-
 ?