EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.3.2.6 | albumin | stimulates aminopeptidase activity | Cavia porcellus | |
3.3.2.6 | albumin | stimulates aminopeptidase activity | Mus musculus | |
3.3.2.6 | albumin | stimulates aminopeptidase activity | Homo sapiens | |
3.3.2.6 | albumin | stimulates aminopeptidase activity | Rattus norvegicus | |
3.3.2.6 | Br- | stimulates aminopeptidase activity | Cavia porcellus | |
3.3.2.6 | Br- | stimulates aminopeptidase activity | Mus musculus | |
3.3.2.6 | Br- | stimulates aminopeptidase activity | Homo sapiens | |
3.3.2.6 | Br- | stimulates aminopeptidase activity | Rattus norvegicus | |
3.3.2.6 | Cl- | stimulates aminopeptidase activity | Cavia porcellus | |
3.3.2.6 | Cl- | stimulates aminopeptidase activity | Mus musculus | |
3.3.2.6 | Cl- | stimulates aminopeptidase activity | Homo sapiens | |
3.3.2.6 | Cl- | stimulates aminopeptidase activity | Rattus norvegicus | |
3.3.2.6 | leukotriene A4 | - |
Saccharomyces cerevisiae | |
3.3.2.6 | SCN- | stimulates aminopeptidase activity | Cavia porcellus | |
3.3.2.6 | SCN- | stimulates aminopeptidase activity | Mus musculus | |
3.3.2.6 | SCN- | stimulates aminopeptidase activity | Homo sapiens | |
3.3.2.6 | SCN- | stimulates aminopeptidase activity | Rattus norvegicus |
EC Number | Application | Comment | Organism |
---|---|---|---|
3.3.2.6 | medicine | the product is a classical chemoattractant, triggers adherence and aggregation of leukocytes to the endothelium, modulates immune responses, participates in the host-defence against infections and is a mediator of PAF-induced lethal shock | Cavia porcellus |
3.3.2.6 | medicine | the product is a classical chemoattractant, triggers adherence and aggregation of leukocytes to the endothelium, modulates immune responses, participates in the host-defence against infections and is a mediator of PAF-induced lethal shock | Mus musculus |
3.3.2.6 | medicine | the product is a classical chemoattractant, triggers adherence and aggregation of leukocytes to the endothelium, modulates immune responses, participates in the host-defence against infections and is a mediator of PAF-induced lethal shock | Homo sapiens |
3.3.2.6 | medicine | the product is a classical chemoattractant, triggers adherence and aggregation of leukocytes to the endothelium, modulates immune responses, participates in the host-defence against infections and is a mediator of PAF-induced lethal shock | Rattus norvegicus |
3.3.2.6 | medicine | the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 | Cavia porcellus |
3.3.2.6 | medicine | the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 | Mus musculus |
3.3.2.6 | medicine | the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 | Homo sapiens |
3.3.2.6 | medicine | the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 | Rattus norvegicus |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
3.3.2.6 | crystal structure of enzyme complexed with bestatin | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.3.2.6 | 2-oxo-3-amino carboxylic esters | - |
Cavia porcellus | |
3.3.2.6 | 2-oxo-3-amino carboxylic esters | - |
Homo sapiens | |
3.3.2.6 | 2-oxo-3-amino carboxylic esters | - |
Mus musculus | |
3.3.2.6 | 2-oxo-3-amino carboxylic esters | - |
Rattus norvegicus | |
3.3.2.6 | 2-oxo-3-amino carboxylic esters | - |
Saccharomyces cerevisiae | |
3.3.2.6 | 2-[4-[4-[2-[1-pyrrolidinyl]ethoxy]phenoxy]phenyl]-oxazole | - |
Homo sapiens | |
3.3.2.6 | bestatin | - |
Cavia porcellus | |
3.3.2.6 | bestatin | - |
Homo sapiens | |
3.3.2.6 | bestatin | - |
Mus musculus | |
3.3.2.6 | bestatin | - |
Rattus norvegicus | |
3.3.2.6 | bestatin | - |
Saccharomyces cerevisiae | |
3.3.2.6 | bestatin | - |
Xenopus laevis | |
3.3.2.6 | captopril | - |
Cavia porcellus | |
3.3.2.6 | captopril | - |
Homo sapiens | |
3.3.2.6 | captopril | - |
Mus musculus | |
3.3.2.6 | captopril | - |
Rattus norvegicus | |
3.3.2.6 | captopril | - |
Saccharomyces cerevisiae | |
3.3.2.6 | Kelatorphan | - |
Cavia porcellus | |
3.3.2.6 | Kelatorphan | - |
Homo sapiens | |
3.3.2.6 | Kelatorphan | - |
Mus musculus | |
3.3.2.6 | Kelatorphan | - |
Rattus norvegicus | |
3.3.2.6 | Kelatorphan | - |
Saccharomyces cerevisiae | |
3.3.2.6 | leukotriene A4 | - |
Cavia porcellus | |
3.3.2.6 | leukotriene A4 | - |
Homo sapiens | |
3.3.2.6 | leukotriene A4 | - |
Mus musculus | |
3.3.2.6 | leukotriene A4 | - |
Rattus norvegicus | |
3.3.2.6 | methyl-N-[3-[4-(phenylmethyl)-phenoxy]propyl]-beta-alanine | - |
Homo sapiens | |
3.3.2.6 | thioamine | - |
Cavia porcellus | |
3.3.2.6 | thioamine | - |
Homo sapiens | |
3.3.2.6 | thioamine | - |
Mus musculus | |
3.3.2.6 | thioamine | - |
Rattus norvegicus | |
3.3.2.6 | thioamine | - |
Saccharomyces cerevisiae |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.3.2.6 | additional information | - |
Homo sapiens | - |
- |
3.3.2.6 | additional information | - |
Rattus norvegicus | - |
- |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.3.2.6 | Zinc | catalytic zinc site with the signature HEXXH-(X)18-E, three zinc binding ligands: His295, His299 and Glu318 | Cavia porcellus | |
3.3.2.6 | Zinc | catalytic zinc site with the signature HEXXH-(X)18-E, three zinc binding ligands: His295, His299 and Glu318 | Mus musculus | |
3.3.2.6 | Zinc | catalytic zinc site with the signature HEXXH-(X)18-E, three zinc binding ligands: His295, His299 and Glu318 | Homo sapiens | |
3.3.2.6 | Zinc | catalytic zinc site with the signature HEXXH-(X)18-E, three zinc binding ligands: His295, His299 and Glu318 | Rattus norvegicus | |
3.3.2.6 | Zinc | zinc content: 1 mol of zinc per mol of enzyme | Mus musculus | |
3.3.2.6 | Zinc | zinc content: 1 mol of zinc per mol of enzyme | Homo sapiens | |
3.3.2.6 | Zinc | zinc protein | Cavia porcellus | |
3.3.2.6 | Zinc | zinc protein | Mus musculus | |
3.3.2.6 | Zinc | zinc protein | Homo sapiens | |
3.3.2.6 | Zinc | zinc protein | Saccharomyces cerevisiae | |
3.3.2.6 | Zinc | zinc protein | Xenopus laevis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.3.2.6 | leukotriene A4 + H2O | Homo sapiens | biosynthesis of leukotriene B4 | leukotriene B4 | - |
? | |
3.3.2.6 | leukotriene A4 + H2O | Rattus norvegicus | biosynthesis of leukotriene B4 | leukotriene B4 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.3.2.6 | Cavia porcellus | - |
- |
- |
3.3.2.6 | Homo sapiens | - |
- |
- |
3.3.2.6 | Mus musculus | - |
- |
- |
3.3.2.6 | Rattus norvegicus | - |
- |
- |
3.3.2.6 | Saccharomyces cerevisiae | - |
- |
- |
3.3.2.6 | Xenopus laevis | - |
- |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
3.3.2.6 | leukotriene A4 + H2O = leukotriene B4 | His295, His299, Glu318, Glu271 are amino acids involved in metallic binding and epoxid hydrolase activity, additional Glu296 and Tyr383 are required for the aminopeptidase activity | Cavia porcellus | |
3.3.2.6 | leukotriene A4 + H2O = leukotriene B4 | His295, His299, Glu318, Glu271 are amino acids involved in metallic binding and epoxid hydrolase activity, additional Glu296 and Tyr383 are required for the aminopeptidase activity | Mus musculus | |
3.3.2.6 | leukotriene A4 + H2O = leukotriene B4 | His295, His299, Glu318, Glu271 are amino acids involved in metallic binding and epoxid hydrolase activity, additional Glu296 and Tyr383 are required for the aminopeptidase activity | Homo sapiens | |
3.3.2.6 | leukotriene A4 + H2O = leukotriene B4 | His295, His299, Glu318, Glu271 are amino acids involved in metallic binding and epoxid hydrolase activity, additional Glu296 and Tyr383 are required for the aminopeptidase activity | Rattus norvegicus | |
3.3.2.6 | leukotriene A4 + H2O = leukotriene B4 | mechanistic models, Glu271 is specifically required for the epoxid hydrolase activity and peptidase activity | Cavia porcellus | |
3.3.2.6 | leukotriene A4 + H2O = leukotriene B4 | mechanistic models, Glu271 is specifically required for the epoxid hydrolase activity and peptidase activity | Mus musculus | |
3.3.2.6 | leukotriene A4 + H2O = leukotriene B4 | mechanistic models, Glu271 is specifically required for the epoxid hydrolase activity and peptidase activity | Homo sapiens | |
3.3.2.6 | leukotriene A4 + H2O = leukotriene B4 | mechanistic models, Glu271 is specifically required for the epoxid hydrolase activity and peptidase activity | Rattus norvegicus | |
3.3.2.6 | leukotriene A4 + H2O = leukotriene B4 | mechanistic models, Glu271 is specifically required for the epoxid hydrolase activity and peptidase activity | Saccharomyces cerevisiae | |
3.3.2.6 | leukotriene A4 + H2O = leukotriene B4 | bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase | Cavia porcellus | |
3.3.2.6 | leukotriene A4 + H2O = leukotriene B4 | bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase | Mus musculus | |
3.3.2.6 | leukotriene A4 + H2O = leukotriene B4 | bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase | Homo sapiens | |
3.3.2.6 | leukotriene A4 + H2O = leukotriene B4 | bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase | Rattus norvegicus | |
3.3.2.6 | leukotriene A4 + H2O = leukotriene B4 | bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase | Saccharomyces cerevisiae | |
3.3.2.6 | leukotriene A4 + H2O = leukotriene B4 | bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase | Xenopus laevis |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.3.2.6 | leukotriene A4 + H2O | model for the binding of leukotriene A4 to the active site | Saccharomyces cerevisiae | leukotriene B4 | - |
? | |
3.3.2.6 | leukotriene A4 + H2O | model for the binding of leukotriene A4 to the active site | Xenopus laevis | leukotriene B4 | - |
? | |
3.3.2.6 | leukotriene A4 + H2O | model for the binding of leukotriene A4 to the active site | Cavia porcellus | leukotriene B4 | mutants of Tyr378 are able to generate, not only leukotriene B4, but also (5S,12R)-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid, in a yield of about 20-30% | ? | |
3.3.2.6 | leukotriene A4 + H2O | model for the binding of leukotriene A4 to the active site | Mus musculus | leukotriene B4 | mutants of Tyr378 are able to generate, not only leukotriene B4, but also (5S,12R)-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid, in a yield of about 20-30% | ? | |
3.3.2.6 | leukotriene A4 + H2O | model for the binding of leukotriene A4 to the active site | Homo sapiens | leukotriene B4 | mutants of Tyr378 are able to generate, not only leukotriene B4, but also (5S,12R)-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid, in a yield of about 20-30% | ? | |
3.3.2.6 | leukotriene A4 + H2O | model for the binding of leukotriene A4 to the active site | Rattus norvegicus | leukotriene B4 | mutants of Tyr378 are able to generate, not only leukotriene B4, but also (5S,12R)-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid, in a yield of about 20-30% | ? | |
3.3.2.6 | leukotriene A4 + H2O | biosynthesis of leukotriene B4 | Homo sapiens | leukotriene B4 | - |
? | |
3.3.2.6 | leukotriene A4 + H2O | biosynthesis of leukotriene B4 | Rattus norvegicus | leukotriene B4 | - |
? | |
3.3.2.6 | additional information | - |
Saccharomyces cerevisiae | ? | - |
? | |
3.3.2.6 | additional information | - |
Xenopus laevis | ? | - |
? | |
3.3.2.6 | additional information | the aminopeptidase activity accepts a variety of substrates and certain arginyl di- and tri-peptides as well as p-nitroanilide derivates of Ala and Arg | Cavia porcellus | ? | - |
? | |
3.3.2.6 | additional information | the aminopeptidase activity accepts a variety of substrates and certain arginyl di- and tri-peptides as well as p-nitroanilide derivates of Ala and Arg | Mus musculus | ? | - |
? | |
3.3.2.6 | additional information | the aminopeptidase activity accepts a variety of substrates and certain arginyl di- and tri-peptides as well as p-nitroanilide derivates of Ala and Arg | Homo sapiens | ? | - |
? | |
3.3.2.6 | additional information | the aminopeptidase activity accepts a variety of substrates and certain arginyl di- and tri-peptides as well as p-nitroanilide derivates of Ala and Arg | Rattus norvegicus | ? | - |
? |