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Literature summary extracted from

  • Iversen, L.; Kristensen, P.; Nissen, J.B.; Merrick, W.C.; Kragballe, K.
    Purification and characterization of leukotriene A4 hydrolase from human epidermis (1995), FEBS Lett., 358, 316-322.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.3.2.6 medicine the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.3.2.6 70000
-
 x * 70000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O Homo sapiens central enzyme in leukotriene B4 formation, it is likely to be involved in transcellular leukotriene formation leukotriene B4
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.6 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.3.2.6
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.6 epidermis
-
 Homo sapiens
-
3.3.2.6 keratinocyte cultured Homo sapiens
-
3.3.2.6 neutrophil
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.3.2.6 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O
-
 Homo sapiens leukotriene B4
-
 ?
3.3.2.6 leukotriene A4 + H2O central enzyme in leukotriene B4 formation, it is likely to be involved in transcellular leukotriene formation Homo sapiens leukotriene B4
-
 ?

Subunits

EC Number Subunits Comment Organism
3.3.2.6 ? x * 70000, SDS-PAGE Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.3.2.6 7.5 8.5
-
 Homo sapiens

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.3.2.6 Homo sapiens chromatofocusing
-
 5.1