Literature summary extracted from

Petrikovics, I.; Cheng, T.C.; Papahadjopoulos, D.; Hong, K.; Yin, R.; DeFrank, J.J.; Jaing, J.; Song, Z.H.; McGuinn, W.D.; Sylvester, D.; Pei, L.; Madec, J.; Tamulinas, C.; Jaszberenyi, J.C.; Barcza, T.; Way, J.L.
Long circulating liposomes encapsulating organophosphorus acid anhydrolase in diisopropylfluorophosphate antagonism (2000), Toxicol. Sci., 57, 16-21.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.1.8.2	additional information	an approach using recombinant enzyme encapsulated within sterically stabilized liposomes to enhance diisopropyl fluorophosphates degradation	Alteromonas sp.

Application

EC Number	Application	Comment	Organism
3.1.8.2	degradation	enzyme catalyse the hydrolysis of toxic organophosphorus cholinesterase-inhibiting compounds, including pesticides and chemical nerve agents	Alteromonas sp.
3.1.8.2	degradation	approach to the use of enzyme encapsulated within liposomes, to protect against and treat chemical poisoning	Alteromonas sp.

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
3.1.8.2	1.57	-	sarin	-	Alteromonas sp.
3.1.8.2	2.48	-	soman	-	Alteromonas sp.
3.1.8.2	2.99	-	diisopropyl fluorophosphate	-	Alteromonas sp.
3.1.8.2	14.2	-	paraoxon	-	Alteromonas sp.

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.8.2	Alteromonas sp.	-	liposomes encapsulating enzyme	-

Storage Stability

EC Number	Storage Stability	Organism
3.1.8.2	37°C, liposomes encapsulating enzyme incubated in blood, stable over 2 days	Alteromonas sp.

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.8.2	diisopropyl fluorophosphate + H2O	-	Alteromonas sp.	diisopropyl phosphate + fluoride	-	?
3.1.8.2	paraoxon + H2O	-	Alteromonas sp.	diethylphosphate + 4-nitrophenol	-	?
3.1.8.2	sarin + H2O	-	Alteromonas sp.	?	-	?
3.1.8.2	soman + H2O	-	Alteromonas sp.	?	-	?

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Release 2023.1 (January 2023)