Literature summary extracted from

Ruiz-Larrea, F.; Drummond, A.H.
Pathways of dephosphorylation of 1-D-myo-inositol 1,4,5-trisphosphate in GH3 pituitary tumor cells (1993), Biochim. Biophys. Acta, 1178, 63-72.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.1.3.57	Li+	reversible	Rattus norvegicus
3.1.3.57	Mg2+	inhibition above 4 mM, activates below	Rattus norvegicus

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
3.1.3.57	0.004	0.005	inositol 1,4-bisphosphate	-	Rattus norvegicus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.1.3.57	cytosol	-	Rattus norvegicus	5829	-

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
3.1.3.57	Na+	activation	Rattus norvegicus
3.1.3.57	Na+	activation below 4 mM, inhibition above	Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.1.3.57	D-myo-inositol 1,4-bisphosphate + H2O	Rattus norvegicus	-	D-myo-inositol 4-phosphate + phosphate	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.3.57	Rattus norvegicus	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
3.1.3.57	partial	Rattus norvegicus

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.1.3.57	GH3 cell	-	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.3.57	D-myo-inositol 1,4-bisphosphate + H2O	-	Rattus norvegicus	D-myo-inositol 4-phosphate + phosphate	-	?

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Release 2023.1 (January 2023)