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Literature summary extracted from

  • Hodgkin, M.; Craxton, A.; Parry, J.B.; Hughes, P.J.; Potter, B.V.L.; Michell, R.H.; Kirk, C.J.
    Bovine testis and human erythrocytes contain different subtypes of membrane-associated Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphomonoesterases (1994), Biochem. J., 297, 637-645.
    View publication on PubMedView publication on EuropePMC

General Stability

EC Number General Stability Organism
3.1.3.56 labile at 37°C, activity is stabilized by phorbol dibutyrate Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.56 2,3-bisphosphoglycerate
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.56 0.014
-
 D-myo-inositol 1,4,5-trisphosphate membrane associated enzyme, pH 7.2, 37°C Bos taurus
3.1.3.56 0.022
-
 D-myo-inositol 1,4,5-trisphosphate membrane associated enzyme, pH 7.2, 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.56 membrane
-
 Homo sapiens 16020
-
3.1.3.56 membrane
-
 Bos taurus 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.56 42000
-
 SDS-PAGE, membrane associated enzyme Bos taurus
3.1.3.56 45000
-
 gel filtration, membrane associated enzyme Bos taurus
3.1.3.56 70000
-
 SDS-PAGE, gel filtration, membrane associated enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.56 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O Homo sapiens product is precursor for inositol 1,3,4,5,6-pentiskphosphate via inositol 1,3,4,6-tetraiskphosphate D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O Bos taurus product is precursor for inositol 1,3,4,5,6-pentiskphosphate via inositol 1,3,4,6-tetraiskphosphate D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O Homo sapiens regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O Bos taurus regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.56 Bos taurus
-
-
-
3.1.3.56 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.56 membrane associated enzyme Homo sapiens
3.1.3.56 membrane associated enzyme Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.56 erythrocyte
-
 Homo sapiens
-
3.1.3.56 testis
-
 Homo sapiens
-
3.1.3.56 testis
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.56 2.7
-
 purified membrane associated enzyme, pH 7.2, 37°C Homo sapiens
3.1.3.56 175
-
 purified membrane associated enzyme, pH 7.2, 37°C Bos taurus

Storage Stability

EC Number Storage Stability Organism
3.1.3.56 -20°C, no loss of activity during long term storage Homo sapiens
3.1.3.56 -80°C, no loss of activity during long term storage Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.56 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
-
 Homo sapiens D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
-
 Bos taurus D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O product is precursor for inositol 1,3,4,5,6-pentiskphosphate via inositol 1,3,4,6-tetraiskphosphate Homo sapiens D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O product is precursor for inositol 1,3,4,5,6-pentiskphosphate via inositol 1,3,4,6-tetraiskphosphate Bos taurus D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O
-
 Homo sapiens D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O
-
 Bos taurus D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate Homo sapiens D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate Bos taurus D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.3.56 monomer 1 * 70000, gel filtration, SDS-PAGE Homo sapiens
3.1.3.56 monomer 1 * 42000, gel filtration, SDS-PAGE Bos taurus