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Literature summary extracted from

  • Verjans B.; De Smedt, F.; Lecocq, R.; Vanweyenberg, V.; Moreau, C.; Erneux, C.
    Cloning and expression in E. coli of dog thyroid cDNA encoding a novel inositol 1,4,5-trisphosphate 5-phosphatase (1994), Biochem. J., 300, 85-90.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.56 clone BVCT expressed in Escherichia coli Canis lupus familiaris

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.56 2,3-bisphosphoglycerate
-
 Canis lupus familiaris
3.1.3.56 EDTA
-
 Bos taurus
3.1.3.56 EDTA
-
 Canis lupus familiaris

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.56 0.003
-
 D-myo-Inositol 1,3,4,5-tetrakisphosphate recombinant enzyme from E. coli Canis lupus familiaris
3.1.3.56 0.028
-
 D-myo-inositol 1,4,5-trisphosphate recombinant enzyme from E. coli Canis lupus familiaris

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.56 43000
-
 SDS-PAGE, type I enzyme Bos taurus
3.1.3.56 47680
-
 calculated from DNA sequence Canis lupus familiaris

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.56 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O Bos taurus
-
 D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O Canis lupus familiaris
-
 D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O Bos taurus regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O Canis lupus familiaris regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.56 Bos taurus
-
-
-
3.1.3.56 Canis lupus familiaris Q29467 sequence of clone BVCT
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.56
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.56 brain
-
 Bos taurus
-
3.1.3.56 thyroid gland
-
 Canis lupus familiaris
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.56 0.089
-
 recombinant enzyme from Escherichia coli Canis lupus familiaris

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.56 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
-
 Bos taurus D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
-
 Canis lupus familiaris D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O
-
 Bos taurus D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O
-
 Canis lupus familiaris D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate Bos taurus D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
3.1.3.56 D-myo-inositol 1,4,5-trisphosphate + H2O regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate Canis lupus familiaris D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?