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Literature summary extracted from

  • Wilcke, M.; Alexson, S.E.H.
    Characterization of acyl-CoA thioesterase activity in isolated rat liver peroxisomes. Partial purification and characterization of a long-chain acyl-CoA thioesterase (1994), Eur. J. Biochem., 222, 803-811.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.2.2 di(2-ethylhexyl)phthalate induces the mitochondrial enzyme by 10fold Rattus norvegicus
3.1.2.18 di(2-ethylhexyl)phthalate 1-2fold increased activity Rattus norvegicus
3.1.2.20 di(2-ethylhexyl)phthalate induces the mitochondrial enzyme by 10fold Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.2.2 albumin
-
 Rattus norvegicus
3.1.2.20 albumin
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.2.2 cytosol
-
 Rattus norvegicus 5829
-
3.1.2.2 microsome
-
 Rattus norvegicus
-
-
3.1.2.2 mitochondrion
-
 Rattus norvegicus 5739
-
3.1.2.2 peroxisome
-
 Rattus norvegicus 5777
-
3.1.2.18 mitochondrion
-
 Rattus norvegicus 5739
-
3.1.2.18 peroxisome
-
 Rattus norvegicus 5777
-
3.1.2.20 cytosol
-
 Rattus norvegicus 5829
-
3.1.2.20 microsome
-
 Rattus norvegicus
-
-
3.1.2.20 mitochondrion
-
 Rattus norvegicus 5739
-
3.1.2.20 peroxisome
-
 Rattus norvegicus 5777
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.2.2 40000
-
 1 * 40000, SDS-PAGE Rattus norvegicus
3.1.2.20 40000
-
 1 * 40000, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.2.2 palmitoyl-CoA + H2O Rattus norvegicus
-
 CoA + palmitate
-
 ?
3.1.2.18 acyl-CoA + H2O Rattus norvegicus
-
 CoA + a carboxylate
-
 ?
3.1.2.20 palmitoyl-CoA + H2O Rattus norvegicus
-
 CoA + palmitate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.2 Rattus norvegicus
-
-
-
3.1.2.18 Rattus norvegicus
-
-
-
3.1.2.20 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.2.2 260fold Rattus norvegicus
3.1.2.2 partial Rattus norvegicus
3.1.2.20 260fold Rattus norvegicus
3.1.2.20 partial Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.2 liver
-
 Rattus norvegicus
-
3.1.2.18 liver
-
 Rattus norvegicus
-
3.1.2.20 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.2 acyl-CoA + H2O
-
 Rattus norvegicus CoA + a carboxylate
-
 ?
3.1.2.2 hexadecanoyl-CoA + H2O i.e. palmitoyl-CoA Rattus norvegicus CoA + hexadecanoate
-
 ?
3.1.2.2 octadecanoyl-CoA + H2O i.e. stearoyl-CoA Rattus norvegicus CoA + octadecanoate
-
 ?
3.1.2.2 palmitoyl-CoA + H2O
-
 Rattus norvegicus CoA + palmitate
-
 ?
3.1.2.2 propionyl-CoA + H2O
-
 Rattus norvegicus CoA + propionate
-
 ?
3.1.2.2 tetradecanoyl-CoA + H2O i.e. myristoyl-CoA Rattus norvegicus CoA + tetradecanoate
-
 ?
3.1.2.18 acyl-CoA + H2O
-
 Rattus norvegicus CoA + a carboxylate
-
 ?
3.1.2.18 propionyl-CoA + H2O
-
 Rattus norvegicus CoA + propionate
-
 ?
3.1.2.20 acyl-CoA + H2O
-
 Rattus norvegicus CoA + a carboxylate
-
 ?
3.1.2.20 hexadecanoyl-CoA + H2O i.e. palmitoyl-CoA Rattus norvegicus CoA + hexadecanoate
-
 ?
3.1.2.20 octadecanoyl-CoA + H2O i.e. stearoyl-CoA Rattus norvegicus CoA + octadecanoate
-
 ?
3.1.2.20 palmitoyl-CoA + H2O
-
 Rattus norvegicus CoA + palmitate
-
 ?
3.1.2.20 propionyl-CoA + H2O
-
 Rattus norvegicus CoA + propionate
-
 ?
3.1.2.20 tetradecanoyl-CoA + H2O i.e. myristoyl-CoA Rattus norvegicus CoA + tetradecanoate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.2.2 monomer 1 * 40000, SDS-PAGE Rattus norvegicus
3.1.2.20 monomer 1 * 40000, SDS-PAGE Rattus norvegicus