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Literature summary extracted from
- Mutagenesis and characterization of specific residues in fatty acid ethyl ester synthase: A gene for alcohol-induced cardiomyopathy (1998), Mol. Cell. Biochem., 180, 111-115.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.1.1.67 | native and mutant forms of FAEES-III cDNA are cloned and expressed in COS-7 cells | Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.1.1.67 | C39W | mutation does not affect FAEES activity | Homo sapiens |
| 3.1.1.67 | G32Q | mutation does not affect FAEES activity | Homo sapiens |
| 3.1.1.67 | H72S | mutation does not affect FAEES activity, less than 9% of control glutathione S-transferase activity | Homo sapiens |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.67 | 26000 | - |
x * 26000, FAEES-III, immunoblot analysis | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.67 | additional information | Homo sapiens | FAEES-III metabolizes both ethanol and carcinogens | ? | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.67 | Homo sapiens | - |
FAEES-III | - |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 3.1.1.67 | a long-chain-fatty-acyl ethyl ester + H2O = a long-chain-fatty acid + ethanol | mechanism | Homo sapiens |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.67 | 0.0006 | - |
native FAEES-III and mutants G32Q, C39W, H72S | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.67 | fatty acid + ethanol | - |
Homo sapiens | fatty acyl ethyl ester + H2O | - |
? | |
| 3.1.1.67 | additional information | FAEES-III also catalyzes the glutathione S-transferase reaction | Homo sapiens | ? | - |
? | |
| 3.1.1.67 | additional information | FAEES-III metabolizes both ethanol and carcinogens | Homo sapiens | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.1.1.67 | ? | x * 26000, FAEES-III, immunoblot analysis | Homo sapiens |
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