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Literature summary extracted from

  • Chetrite, G.S.; Kloosterboer, H.J.; Philippe, J.C.; Pasqualini, J.R.
    Effect of Org OD14 (LIVIAL) and its metabolites on human estrogen sulphotransferase activity in the hormone-dependent MCF-7 and T-47D, and the hormone-independent MDA-MB-231, breast cancer cell lines (1999), Anticancer Res., 19, 269-275.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.8.2.4 17-hydroxy-19-nor-7-methyl-17-pregn-5(10)-en-20-yn-3-one Org OD14, active substance in Livial (R), 0.0005-0.00005 mM stimulates the formation of estrone by 40-60%, no effect in MDA-MB-231 cells Homo sapiens

Application

EC Number Application Comment Organism
2.8.2.4 medicine formation of inactive estrogen sulfates can cause a reduction in the estrogenic environment which confers a beneficial effect to Org OD14 reducing the risk of breast tumours in long-term hormone replacement treatment Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.4 OrgOD14 active substance in Livial (r), above 0.05 mM decreases significantly biosynthesis of estrone by 50-60%, no effect in MDA-MB-231 cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.4 cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.4 3'-phosphoadenylylsulfate + estrone Homo sapiens
-
 adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.4 Homo sapiens
-
 human
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.4 breast cancer cell line hormone-dependent MCF-7 and T47D, hormone-independent MDA-MB-231 Homo sapiens
-
2.8.2.4 MCF-7 cell hormone-dependent breast cancer cell line Homo sapiens
-
2.8.2.4 MDA-MB-231 cell hormone-independent breast cancer cell line Homo sapiens
-
2.8.2.4 T47D cell hormone-dependent breast cancer cell line Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.4 3'-phosphoadenylylsulfate + estrone
-
 Homo sapiens adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 r