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Literature summary extracted from

  • Aksoy, I.A.; Wood, T.C.; Weinshilboum, R.
    Human liver estrogen sulfotransferase: identification by cDNA cloning and expression (1994), Biochem. Biophys. Res. Commun., 200, 1621-1629.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.8.2.4 NaCl activity of liver EST transiently expressed in COS-1 cells increases 86% in presence of 150 mM Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.4 EST cDNA cloned and expressed in COS-1 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.4 2,6-Dichloro-4-nitrophenol
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.4 0.00017
-
 estrone pH 6.5, 37°C Homo sapiens
2.8.2.4 0.00085
-
 dehydroepiandrosterone pH 6.5, 37°C Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.8.2.4 Mg2+ 1.25 mM increases EST activity 20% with estrone as substrate Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.4 3'-phosphoadenylylsulfate + estrone Homo sapiens
-
 adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.4 Homo sapiens
-
 human
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.4 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.4 3'-phosphoadenylylsulfate + dehydroepiandrosterone
-
 Homo sapiens adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 r
2.8.2.4 3'-phosphoadenylylsulfate + estrone
-
 Homo sapiens adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 r
2.8.2.4 3'-phosphoadenylylsulfate + p-nitrophenol
-
 Homo sapiens adenosine 3',5'-bisphosphate + p-nitrophenyl sulfate
-
 r
2.8.2.4 additional information dopamine is no substrate Homo sapiens ?
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.8.2.4 30 45 thermal inactivation at 45°C Homo sapiens