BRENDA - Enzyme Database show

IV. Synthesis and assay of analogs of adenosine 3,5-diphosphate as inhibitors of bovine adrenal estrogen sulfotranferase

Horwitz, J.P.; Misra, R.S.; Rozhin, J.; Neenan, J.P.; Huo, A.; Godefroi, V.E.; Philips, K.D.; Chung, H.L.; Butke, G.; Brooks, S.C.; Biochim. Biophys. Acta 525, 364-372 (1978)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.8.2.4
(7-amino-3(beta-D-ribofuranosyl)-pyrazolo-[4,3-d]pyrimidine) 3',5'-diphosphate
-
Bos taurus
2.8.2.4
3'-AMP
-
Bos taurus
2.8.2.4
7-deazadenosine
tubercidin
Bos taurus
2.8.2.4
8-bromoadenosine 3',5'-diphosphate
-
Bos taurus
2.8.2.4
adenosine 3',5'-diphosphate
-
Bos taurus
2.8.2.4
adenosine 3'-diphosphate 5'-phosphate
-
Bos taurus
2.8.2.4
adenosine 3'-phosphate 5'-diphosphate
-
Bos taurus
2.8.2.4
adenosine 5'-phosphosulfate
-
Bos taurus
2.8.2.4
adenosine 5'-sulfate
-
Bos taurus
2.8.2.4
adenosine N1-oxide 3,5'-diphosphate
-
Bos taurus
2.8.2.4
AMP
-
Bos taurus
2.8.2.4
guanosine 2',3'-cyclic phosphate 5'-phosphate
-
Bos taurus
2.8.2.4
inosine 3',5'-diphosphate
-
Bos taurus
2.8.2.4
N6-dimethylaminoadenosine 3',5'-diphosphate
-
Bos taurus
2.8.2.4
nebularine(9-beta-D-ribofuranosylpurine)adenosine 3',5'-diphosphate
-
Bos taurus
2.8.2.4
tubercidin 2',5'-diphosphate
-
Bos taurus
2.8.2.4
tubercidin 3',5'-bisphosphate
-
Bos taurus
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.8.2.4
0.044
-
adenosine 3'-phosphate 5'-phosphosulfate
pH 7.5, 37°C
Bos taurus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.8.2.4
3'-phosphoadenylylsulfate + estrone
Bos taurus
-
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
Bos taurus
r
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.8.2.4
Bos taurus
-
bovine
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.8.2.4
adrenal gland
-
Bos taurus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.8.2.4
3'-phosphoadenylylsulfate + estrone
-
645873
Bos taurus
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
645873
Bos taurus
r
2.8.2.4
additional information
simple phenols or steroid alcohols are no substrates
645873
Bos taurus
?
-
-
-
-
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
2.8.2.4
0.0006
-
tubercidin 3',5'-bisphosphate
pH 7.5, 37°C
Bos taurus
2.8.2.4
0.0017
-
8-bromoadenosine 3',5'-diphosphate
pH 7.5, 37°C
Bos taurus
2.8.2.4
0.0053
-
tubercidin 2',5'-diphosphate
pH 7.5, 37°C
Bos taurus
2.8.2.4
0.007
-
adenosine 3',5'-diphosphate
pH 7.5, 37°C
Bos taurus
2.8.2.4
0.043
-
(7-amino-3(beta-D-ribofuranosyl)-pyrazolo-[4,3-d]pyrimidine) 3,5''-diphosphate
pH 7.5, 37°C
Bos taurus
2.8.2.4
0.046
-
adenosine 3'-diphosphate 5'-phosphate
pH 7.5, 37°C
Bos taurus
2.8.2.4
0.068
-
nebularine(9-beta-D-ribofuranosylpurine)adenosine 3',5'-diphosphate
pH 7.5, 37°C
Bos taurus
2.8.2.4
0.084
-
guanosine 2',3'-cyclic phosphate 5'-phosphate
pH 7.5, 37°C
Bos taurus
2.8.2.4
0.116
-
adenosine 3'-phosphate 5'-diphosphate
pH 7.5, 37°C
Bos taurus
2.8.2.4
0.125
-
N6-dimethylaminoadenosine 3',5'-diphosphate
pH 7.5, 37°C
Bos taurus
2.8.2.4
0.35
-
adenosine N1-oxide 3,5'-diphosphate
pH 7.5, 37°C
Bos taurus
2.8.2.4
0.8
-
inosine 3',5'-diphosphate
pH 7.5, 37°C
Bos taurus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.8.2.4
(7-amino-3(beta-D-ribofuranosyl)-pyrazolo-[4,3-d]pyrimidine) 3',5'-diphosphate
-
Bos taurus
2.8.2.4
3'-AMP
-
Bos taurus
2.8.2.4
7-deazadenosine
tubercidin
Bos taurus
2.8.2.4
8-bromoadenosine 3',5'-diphosphate
-
Bos taurus
2.8.2.4
adenosine 3',5'-diphosphate
-
Bos taurus
2.8.2.4
adenosine 3'-diphosphate 5'-phosphate
-
Bos taurus
2.8.2.4
adenosine 3'-phosphate 5'-diphosphate
-
Bos taurus
2.8.2.4
adenosine 5'-phosphosulfate
-
Bos taurus
2.8.2.4
adenosine 5'-sulfate
-
Bos taurus
2.8.2.4
adenosine N1-oxide 3,5'-diphosphate
-
Bos taurus
2.8.2.4
AMP
-
Bos taurus
2.8.2.4
guanosine 2',3'-cyclic phosphate 5'-phosphate
-
Bos taurus
2.8.2.4
inosine 3',5'-diphosphate
-
Bos taurus
2.8.2.4
N6-dimethylaminoadenosine 3',5'-diphosphate
-
Bos taurus
2.8.2.4
nebularine(9-beta-D-ribofuranosylpurine)adenosine 3',5'-diphosphate
-
Bos taurus
2.8.2.4
tubercidin 2',5'-diphosphate
-
Bos taurus
2.8.2.4
tubercidin 3',5'-bisphosphate
-
Bos taurus
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
2.8.2.4
0.0006
-
tubercidin 3',5'-bisphosphate
pH 7.5, 37°C
Bos taurus
2.8.2.4
0.0017
-
8-bromoadenosine 3',5'-diphosphate
pH 7.5, 37°C
Bos taurus
2.8.2.4
0.0053
-
tubercidin 2',5'-diphosphate
pH 7.5, 37°C
Bos taurus
2.8.2.4
0.007
-
adenosine 3',5'-diphosphate
pH 7.5, 37°C
Bos taurus
2.8.2.4
0.043
-
(7-amino-3(beta-D-ribofuranosyl)-pyrazolo-[4,3-d]pyrimidine) 3,5''-diphosphate
pH 7.5, 37°C
Bos taurus
2.8.2.4
0.046
-
adenosine 3'-diphosphate 5'-phosphate
pH 7.5, 37°C
Bos taurus
2.8.2.4
0.068
-
nebularine(9-beta-D-ribofuranosylpurine)adenosine 3',5'-diphosphate
pH 7.5, 37°C
Bos taurus
2.8.2.4
0.084
-
guanosine 2',3'-cyclic phosphate 5'-phosphate
pH 7.5, 37°C
Bos taurus
2.8.2.4
0.116
-
adenosine 3'-phosphate 5'-diphosphate
pH 7.5, 37°C
Bos taurus
2.8.2.4
0.125
-
N6-dimethylaminoadenosine 3',5'-diphosphate
pH 7.5, 37°C
Bos taurus
2.8.2.4
0.35
-
adenosine N1-oxide 3,5'-diphosphate
pH 7.5, 37°C
Bos taurus
2.8.2.4
0.8
-
inosine 3',5'-diphosphate
pH 7.5, 37°C
Bos taurus
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.8.2.4
0.044
-
adenosine 3'-phosphate 5'-phosphosulfate
pH 7.5, 37°C
Bos taurus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.8.2.4
3'-phosphoadenylylsulfate + estrone
Bos taurus
-
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
Bos taurus
r
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.8.2.4
adrenal gland
-
Bos taurus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.8.2.4
3'-phosphoadenylylsulfate + estrone
-
645873
Bos taurus
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
645873
Bos taurus
r
2.8.2.4
additional information
simple phenols or steroid alcohols are no substrates
645873
Bos taurus
?
-
-
-
-