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Literature summary extracted from

  • Horwitz, J.P.; Misra, R.S.; Rozhin, J.; Neenan, J.P.; Huo, A.; Godefroi, V.E.; Philips, K.D.; Chung, H.L.; Butke, G.; Brooks, S.C.
    IV. Synthesis and assay of analogs of adenosine 3,5-diphosphate as inhibitors of bovine adrenal estrogen sulfotranferase (1978), Biochim. Biophys. Acta, 525, 364-372.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.4 (7-amino-3(beta-D-ribofuranosyl)-pyrazolo-[4,3-d]pyrimidine) 3',5'-diphosphate
-
 Bos taurus
2.8.2.4 3'-AMP
-
 Bos taurus
2.8.2.4 7-deazadenosine tubercidin Bos taurus
2.8.2.4 8-bromoadenosine 3',5'-diphosphate
-
 Bos taurus
2.8.2.4 adenosine 3',5'-diphosphate
-
 Bos taurus
2.8.2.4 adenosine 3'-diphosphate 5'-phosphate
-
 Bos taurus
2.8.2.4 adenosine 3'-phosphate 5'-diphosphate
-
 Bos taurus
2.8.2.4 adenosine 5'-phosphosulfate
-
 Bos taurus
2.8.2.4 adenosine 5'-sulfate
-
 Bos taurus
2.8.2.4 adenosine N1-oxide 3,5'-diphosphate
-
 Bos taurus
2.8.2.4 AMP
-
 Bos taurus
2.8.2.4 guanosine 2',3'-cyclic phosphate 5'-phosphate
-
 Bos taurus
2.8.2.4 inosine 3',5'-diphosphate
-
 Bos taurus
2.8.2.4 N6-dimethylaminoadenosine 3',5'-diphosphate
-
 Bos taurus
2.8.2.4 nebularine(9-beta-D-ribofuranosylpurine)adenosine 3',5'-diphosphate
-
 Bos taurus
2.8.2.4 tubercidin 2',5'-diphosphate
-
 Bos taurus
2.8.2.4 tubercidin 3',5'-bisphosphate
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.4 0.044
-
 adenosine 3'-phosphate 5'-phosphosulfate pH 7.5, 37°C Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.4 3'-phosphoadenylylsulfate + estrone Bos taurus
-
 adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.4 Bos taurus
-
 bovine
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.4 adrenal gland
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.4 3'-phosphoadenylylsulfate + estrone
-
 Bos taurus adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 r
2.8.2.4 additional information simple phenols or steroid alcohols are no substrates Bos taurus ?
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.8.2.4 0.0006
-
 tubercidin 3',5'-bisphosphate pH 7.5, 37°C Bos taurus
2.8.2.4 0.0017
-
 8-bromoadenosine 3',5'-diphosphate pH 7.5, 37°C Bos taurus
2.8.2.4 0.0053
-
 tubercidin 2',5'-diphosphate pH 7.5, 37°C Bos taurus
2.8.2.4 0.007
-
 adenosine 3',5'-diphosphate pH 7.5, 37°C Bos taurus
2.8.2.4 0.043
-
 (7-amino-3(beta-D-ribofuranosyl)-pyrazolo-[4,3-d]pyrimidine) 3,5''-diphosphate pH 7.5, 37°C Bos taurus
2.8.2.4 0.046
-
 adenosine 3'-diphosphate 5'-phosphate pH 7.5, 37°C Bos taurus
2.8.2.4 0.068
-
 nebularine(9-beta-D-ribofuranosylpurine)adenosine 3',5'-diphosphate pH 7.5, 37°C Bos taurus
2.8.2.4 0.084
-
 guanosine 2',3'-cyclic phosphate 5'-phosphate pH 7.5, 37°C Bos taurus
2.8.2.4 0.116
-
 adenosine 3'-phosphate 5'-diphosphate pH 7.5, 37°C Bos taurus
2.8.2.4 0.125
-
 N6-dimethylaminoadenosine 3',5'-diphosphate pH 7.5, 37°C Bos taurus
2.8.2.4 0.35
-
 adenosine N1-oxide 3,5'-diphosphate pH 7.5, 37°C Bos taurus
2.8.2.4 0.8
-
 inosine 3',5'-diphosphate pH 7.5, 37°C Bos taurus