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Literature summary extracted from

  • Barker, E.V.; Hume, R.; Hallas, A.; Coughtrie, W.H.
    Dehydroepiandrosterone sulfotransferase in the developing human fetus: quantitative biochemical and immunological characterization of the hepatic, renal, and adrenal enzymes (1994), Endocrinology, 134, 982-989.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.2 cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.2 3'-phosphoadenylylsulfate + dehydroepiandrosterone Homo sapiens critical step in the provision of substrates for estrogen biosynthesis by the placenta during pregnancy, sulfation represents a major enzymatic reaction in the metabolism, excretion and homeostasis of steroid hormones and bile acids in addition to numerous other endogenous compounds and xenobiotics, regulating steroid hormone bioactivity adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.2 Homo sapiens
-
 human
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.2 adrenal gland
-
 Homo sapiens
-
2.8.2.2 embryo
-
 Homo sapiens
-
2.8.2.2 fetus
-
 Homo sapiens
-
2.8.2.2 hepatocyte
-
 Homo sapiens
-
2.8.2.2 kidney present in proximal and distal tubules, loops of Henle and collecting ducts, but at no time expressed in the vascular glomerulus Homo sapiens
-
2.8.2.2 liver
-
 Homo sapiens
-
2.8.2.2 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.2 3'-phosphoadenylylsulfate + dehydroepiandrosterone
-
 Homo sapiens adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 r
2.8.2.2 3'-phosphoadenylylsulfate + dehydroepiandrosterone critical step in the provision of substrates for estrogen biosynthesis by the placenta during pregnancy, sulfation represents a major enzymatic reaction in the metabolism, excretion and homeostasis of steroid hormones and bile acids in addition to numerous other endogenous compounds and xenobiotics, regulating steroid hormone bioactivity Homo sapiens adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.8.2.2 DHEA ST
-
 Homo sapiens