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Literature summary extracted from
- Steroid sulphotransferase and 17beta-hydroxysteroid dehydrogenase activities in Ishikawa human endometrial adenocarcinoma cells (1997), J. Steroid Biochem. Mol. Biol., 61, 27-34.
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 2.8.2.4 | 0.0000105 | - |
estradiol | pH 7.4, 37°C, Ishikawa cells | Homo sapiens |  |
| 2.8.2.15 | 0.00001 | - |
17beta-estradiol | pH 7.4, 37°C | Homo sapiens | |
| 2.8.2.15 | 0.0000105 | - |
estrone | pH 7.4, 37°C | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.8.2.4 | 3'-phosphoadenylylsulfate + estradiol | Homo sapiens | - |
adenosine 3',5'-bisphosphate + estradiol 3-sulfate | - |
r | |
| 2.8.2.4 | 3'-phosphoadenylylsulfate + estrone | Homo sapiens | - |
adenosine 3',5'-bisphosphate + estrone 3-sulfate | - |
r | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.8.2.4 | Homo sapiens | - |
human | - |
| 2.8.2.15 | Homo sapiens | - |
human | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 2.8.2.4 | adenocarcinoma cell | Ishikawa endometrial adenocarcinoma | Homo sapiens | - |
| 2.8.2.15 | endometrial cell line | Ishikawa adenocarcinoma | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.8.2.4 | 3'-phosphoadenylylsulfate + estradiol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + estradiol 3-sulfate | - |
r | |
| 2.8.2.4 | 3'-phosphoadenylylsulfate + estriol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + estriol 3-sulfate | - |
r | |
| 2.8.2.4 | 3'-phosphoadenylylsulfate + estrone | - |
Homo sapiens | adenosine 3',5'-bisphosphate + estrone 3-sulfate | - |
r | |
| 2.8.2.15 | 3'-phosphoadenylylsulfate + 17beta-estradiol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
r | |
| 2.8.2.15 | 3'-phosphoadenylylsulfate + estriol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + estriol sulfate | - |
r | |
| 2.8.2.15 | 3'-phosphoadenylylsulfate + estrone | - |
Homo sapiens | adenosine 3',5'-bisphosphate + estrone sulfate | - |
r | |
| 2.8.2.15 | additional information | very limited sulfotransferase activity against dehydroepiandrosterone, testosterone and pregnenolone | Homo sapiens | ? | - |
? | |
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