BRENDA - Enzyme Database show

Identification of a new adult human liver sulfotransferase with specificity for endogenous and xenobiotic estrogens

Forbes-Bamforth, K.J.; Coughtrie, M.W.H.; Biochem. Biophys. Res. Commun. 198, 707-711 (1994)

Data extracted from this reference:

Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.8.2.4
cytosol
-
Homo sapiens
5829
-
2.8.2.15
cytosol
-
Homo sapiens
5829
-
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.8.2.4
35000
-
2 * 35000, immunoblot analysis
Homo sapiens
2.8.2.15
33000
-
immunoblot analysis, antibodies against rat liver sulfotransferases
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.8.2.4
3'-phosphoadenylylsulfate + estrone
Homo sapiens
-
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
Homo sapiens
r
2.8.2.15
3'-phosphoadenylylsulfate + dehydroepiandrosterone
Homo sapiens
sulfation is an important pathway for biotransformation and inactivation of drugs, xenobiotics, monoamine and catecholamine neurotransmitters and steroid hormones
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
Homo sapiens
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.8.2.4
Homo sapiens
-
human
-
2.8.2.15
Homo sapiens
-
human
-
Purification (Commentary)
EC Number
Commentary
Organism
2.8.2.4
-
Homo sapiens
2.8.2.15
-
Homo sapiens
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.8.2.4
liver
-
Homo sapiens
-
2.8.2.15
liver
isoenzyme in adult liver
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.8.2.4
3'-phosphoadenylylsulfate + 17alpha ethinyl estradiol
-
645731
Homo sapiens
adenosine 3',5'-bisphosphate + 17alpha ethinyl estradiol 3-sulfate
-
645731
Homo sapiens
r
2.8.2.4
3'-phosphoadenylylsulfate + estrone
-
645731
Homo sapiens
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
645731
Homo sapiens
r
2.8.2.15
3'-phosphoadenylylsulfate + dehydroepiandrosterone
sulfation is an important pathway for biotransformation and inactivation of drugs, xenobiotics, monoamine and catecholamine neurotransmitters and steroid hormones
645731
Homo sapiens
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
645731
Homo sapiens
-
2.8.2.15
3'-phosphoadenylylsulfate + estrone
-
645731
Homo sapiens
adenosine 3',5'-bisphosphate + estrone sulfate
-
645731
Homo sapiens
r
2.8.2.15
additional information
specific for endogenous and xenobiotic estrogens
645731
Homo sapiens
?
-
-
-
-
Subunits
EC Number
Subunits
Commentary
Organism
2.8.2.4
dimer
2 * 35000, immunoblot analysis
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.8.2.4
cytosol
-
Homo sapiens
5829
-
2.8.2.15
cytosol
-
Homo sapiens
5829
-
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.8.2.4
35000
-
2 * 35000, immunoblot analysis
Homo sapiens
2.8.2.15
33000
-
immunoblot analysis, antibodies against rat liver sulfotransferases
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.8.2.4
3'-phosphoadenylylsulfate + estrone
Homo sapiens
-
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
Homo sapiens
r
2.8.2.15
3'-phosphoadenylylsulfate + dehydroepiandrosterone
Homo sapiens
sulfation is an important pathway for biotransformation and inactivation of drugs, xenobiotics, monoamine and catecholamine neurotransmitters and steroid hormones
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
Homo sapiens
-
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
2.8.2.4
-
Homo sapiens
2.8.2.15
-
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.8.2.4
liver
-
Homo sapiens
-
2.8.2.15
liver
isoenzyme in adult liver
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.8.2.4
3'-phosphoadenylylsulfate + 17alpha ethinyl estradiol
-
645731
Homo sapiens
adenosine 3',5'-bisphosphate + 17alpha ethinyl estradiol 3-sulfate
-
645731
Homo sapiens
r
2.8.2.4
3'-phosphoadenylylsulfate + estrone
-
645731
Homo sapiens
adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
645731
Homo sapiens
r
2.8.2.15
3'-phosphoadenylylsulfate + dehydroepiandrosterone
sulfation is an important pathway for biotransformation and inactivation of drugs, xenobiotics, monoamine and catecholamine neurotransmitters and steroid hormones
645731
Homo sapiens
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
645731
Homo sapiens
-
2.8.2.15
3'-phosphoadenylylsulfate + estrone
-
645731
Homo sapiens
adenosine 3',5'-bisphosphate + estrone sulfate
-
645731
Homo sapiens
r
2.8.2.15
additional information
specific for endogenous and xenobiotic estrogens
645731
Homo sapiens
?
-
-
-
-
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
2.8.2.4
dimer
2 * 35000, immunoblot analysis
Homo sapiens