Any feedback?
Literature summary extracted from
- Phenol sulfotransferase 1A1 activity in human liver: kinetic properties, interindividual variation and re-evaluation of the suitability of 4-nitrophenol as a probe substrate (2003), Biochem. Pharmacol., 66, 2089-2097.
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 2.8.2.1 | additional information | - |
additional information | kinetics of SULT1A1 allozymes 1 and 2 with 4-nitrophenol | Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 2.8.2.1 | cytosol | SULT1A1 allozymes 1 and 2 | Homo sapiens | 5829 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.8.2.1 | 3'-phosphoadenylylsulfate + a phenol | Homo sapiens | SULTs, especially SULT1A1, are important in xenobiotic and drug metabolism because of their broad substrate specificity and extensive tissue distribution | adenosine 3',5'-bisphosphate + an aryl sulfate | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.8.2.1 | Homo sapiens | - |
SULT1B1 | - |
| 2.8.2.1 | Homo sapiens | - |
SULT1A1 allozymes 1 and 2 | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 2.8.2.1 | liver | SULT1A1 | Homo sapiens | - |
| 2.8.2.1 | liver | SULT1B1 | Homo sapiens | - |
| 2.8.2.1 | placenta | SULT1A1 alozymes 1 and 2, but no SULT1B1 expression | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 2.8.2.1 | additional information | - |
assay development with 4-nitrophenol to distinguish SULT1A1 allozymes and SULT1B1 from liver | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.8.2.1 | 3'-phosphoadenylyl sulfate + a phenol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + an aryl sulfate | - |
? | |
| 2.8.2.1 | 3'-phosphoadenylylsulfate + 4-nitrophenol | SULT1A1 | Homo sapiens | adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate | - |
? | |
| 2.8.2.1 | 3'-phosphoadenylylsulfate + 4-nitrophenol | SULT1B1 | Homo sapiens | adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate | - |
? | |
| 2.8.2.1 | 3'-phosphoadenylylsulfate + a phenol | SULTs, especially SULT1A1, are important in xenobiotic and drug metabolism because of their broad substrate specificity and extensive tissue distribution | Homo sapiens | adenosine 3',5'-bisphosphate + an aryl sulfate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 2.8.2.1 | SULT | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 2.8.2.1 | 37 | - |
assay at | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 2.8.2.1 | 7.4 | - |
assay at | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
