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Literature summary extracted from

  • Berkovitch, F.; Nicolet, Y.; Wan, J.T.; Jarrett, J.T.; Drennan, C.L.
    Crystal structure of biotin synthase, an S-adenosylmethionine-dependent radical enzyme (2004), Science, 303, 76-79.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.8.1.6 complexed with S-adenosyl-L-methionine and dethiobiotin Escherichia coli
2.8.1.6 in complex with S-adensyl-L-methionine and dethiobiotin Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.8.1.6 Iron [2Fe-2S] and [4Fe-4S] cluster Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
2.8.1.6 Escherichia coli P12996
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.8.1.6 dethiobiotin + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + 2 reduced [2Fe-2S] ferredoxin = biotin + (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine + 2 oxidized [2Fe-2S] ferredoxin substrates are placed between the (4Fe-4S) cluster, essential for radical generation, and the (2Fe-2S) cluster Escherichia coli
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.1.6 dethiobiotin + sulfur
-
 Escherichia coli biotin
-
 ?