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Literature summary extracted from

  • Shaw, N.M.; Birch, O.M.; Tinschert, A.; Venetz, V.; Dietrich, R.; Savoy, L.A.
    Biotin synthase from Escherichia coli: isolation of an enzyme-generated intermediate and stoichiometry of S-adenosylmethionine use (1998), Biochem. J., 330, 1079-1085.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.8.1.6 asparagine required Escherichia coli
2.8.1.6 L-cysteine required Escherichia coli
2.8.1.6 S-adenosyl-L-methionine two molecules of S-adenosyl-L-methionine are used to synthesize one molecule of biotin, one from dethiobiotin to the intermediate, and a second from the intermediate to biotin Escherichia coli

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.1.6
-
 Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
2.8.1.6 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.1.6 dethiobiotin + sulfur
-
 Escherichia coli biotin
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.8.1.6 8 8.5
-
 Escherichia coli