BRENDA - Enzyme Database

Deficiency of UDP-GlcNAc: dolichol phosphate N-acetylglucosamine-1 phosphate transferase (DPAGT1) causes a novel congenital disorder of glycosylation type Ij

Wu, X.; Rush, J.S.; Karaoglu, D.; Krasnewich, D.; Lubinsky, M.S.; Waechter, C.J.; Gilmore, R.; Freeze, H.H.; Hum. Mutat. 22, 144-150 (2003)

Data extracted from this reference:

Engineering
EC Number
Amino acid exchange
Commentary
Organism
2.7.8.15
Y170C
mutant enzyme has almost no activity
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.8.15
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
Homo sapiens
deficiency of UDP-GlcNAc:dolichol phosphate N-acetylglucosamine-1 phosphate transferase (DPAGT1) causes a novel congenital disorder of glycosylation type Ij
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.8.15
Homo sapiens
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.8.15
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
-
645362
Homo sapiens
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
645362
Homo sapiens
?
2.7.8.15
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
deficiency of UDP-GlcNAc:dolichol phosphate N-acetylglucosamine-1 phosphate transferase (DPAGT1) causes a novel congenital disorder of glycosylation type Ij
645362
Homo sapiens
?
-
-
-
-
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
2.7.8.15
Y170C
mutant enzyme has almost no activity
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.8.15
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
Homo sapiens
deficiency of UDP-GlcNAc:dolichol phosphate N-acetylglucosamine-1 phosphate transferase (DPAGT1) causes a novel congenital disorder of glycosylation type Ij
?
-
-
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.8.15
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
-
645362
Homo sapiens
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
645362
Homo sapiens
?
2.7.8.15
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
deficiency of UDP-GlcNAc:dolichol phosphate N-acetylglucosamine-1 phosphate transferase (DPAGT1) causes a novel congenital disorder of glycosylation type Ij
645362
Homo sapiens
?
-
-
-
-