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Literature summary extracted from

  • Umbreit, J.N.; Strominger, J.L.
    Complex lipid requirements for detergent-solubilized phosphoacetylmuramyl-pentapeptide translocase from Micrococcus luteus (1972), Proc. Natl. Acad. Sci. USA, 69, 1972-1974.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.8.13 Neutral lipid stimulates synthesis of C55-isoprenyl-P-P-MurNAc-pentapeptide from UDPMurNAc-pentapeptide, no effect on exchange reaction of UDP-MurNAc-pentapeptide with UMP Micrococcus luteus
2.7.8.13 Polar lipid fraction required by exchange reaction of UDP-MurNAc-pentapeptide with UMP Micrococcus luteus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.8.13 Triton X-100 activity is lost upon addition, can be restored by addition of lipid fractions to the assay Micrococcus luteus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.8.13 membrane
-
 Micrococcus luteus 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.13 UDP-NAc-muramoyl-pentapeptide + acceptor Micrococcus luteus
-
 UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.13 Micrococcus luteus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.13 UDP-MurNAc-pentapeptide + C55-isoprenyl phosphate
-
 Micrococcus luteus C55-isoprenyl-diphosphate-MurNAc-pentapeptide
-
 r
2.7.8.13 UDP-N-acetylmuramoyl-pentapeptide + [2H]UMP
-
 Micrococcus luteus UMP + [2H]UDP-NAc-muramoyl-pentapeptide
-
 r
2.7.8.13 UDP-NAc-muramoyl-pentapeptide + acceptor
-
 Micrococcus luteus UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
 r