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Literature summary extracted from

  • Munster, A.K.; Eckhardt, M.; Potvin, B.; Muhlenhoff, M.; Stanley, P.; Gerardy-Schahn, R.
    Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs (1998), Proc. Natl. Acad. Sci. USA, 95, 9140-9145.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.43 cloning is achieved by complementation of the Chineses hamster ovary lec32 mutation that causes a deficiency in CMP-N-acetylneuraminate synthetase activity, it also causes polysialic acid to be expressed in the capsule of the CMP-Neu5Ac synthetase negative Escherichia coli mutant EV5 Mus musculus
2.7.7.43 expression in CHO cells or Escherichia coli Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.43 nucleus
-
 Mus musculus 5634
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.7.43 48058
-
 x * 48058, calculation from nucleotide sequence Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.43 CTP + N-acylneuraminate Mus musculus production of CMP-N-acetylneuraminate is required for the synthesis of sialylated glycoconjugates diphosphate + CMP-N-acylneuraminate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.43 Mus musculus Q99KK2
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.43 AtT-20 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.43 CTP + N-acylneuraminate
-
 Mus musculus diphosphate + CMP-N-acylneuraminate
-
 ?
2.7.7.43 CTP + N-acylneuraminate production of CMP-N-acetylneuraminate is required for the synthesis of sialylated glycoconjugates Mus musculus diphosphate + CMP-N-acylneuraminate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.7.43 ? x * 48058, calculation from nucleotide sequence Mus musculus