Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Maness, P.; Orengo, A.
    Activation of rat liver pyrimidine nucleoside monophosphate kinase (1976), Biochim. Biophys. Acta, 429, 182-190.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.4.14 2-mercaptoethanol at 5 mM: reduction in molecular weight from approximately 53000 Da to 17000 Da. This low molecular weight form is partially active in the presence of 2-mercaptoethanol. In absence of 2-mercaptoethanol the low molecular weight form is inactive. At 50 mM: full reactivation of the CMP(ATP) kinase activity followed by dCMP(ATP) and CMP(dCTP) Rattus norvegicus
2.7.4.14 thioredoxin activates Rattus norvegicus

General Stability

EC Number General Stability Organism
2.7.4.14 the enzyme is unstable when fully activated, anions promoting hydrophobic interactions stabilize the active conformation Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.4.14 iodoacetamide
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.14 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.4.14 liver
-
 Rattus norvegicus
-