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Literature summary extracted from

  • Lau, K.S.; Herring, W.J.; Chuang, J.L.; McKean, M.; Danner, D.J.; Cox, R.P.; Chuang, D.T.
    Structure of the gene encoding dihydrolipoyl transacylase (E2) component of human branched chain alpha-keto acid dehydrogenase complex and characterization of an E2 pseudogene (1992), J. Biol. Chem., 267, 24090-24096.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.168 gene contains a mitochondrial targeting presequence Homo sapiens
2.3.1.168 gene E2, DNA sequence determination and analysis Homo sapiens
2.3.1.168 pseudogene E2, DNA sequence determination and analysis, retroposon, gene corresponds to the complete mitochondrial presequence and the lipoyl-bearing domain encoded by exon I through IV of the functional gene E2 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.168 mitochondrion
-
 Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.168 Homo sapiens P11182 gene E2
-
2.3.1.168 Homo sapiens P11182 pseudogene E2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.168 fibroblast
-
 Homo sapiens
-
2.3.1.168 kidney
-
 Homo sapiens
-
2.3.1.168 lymphoblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.168 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine
-
 Homo sapiens CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.168 More enzyme is the E2 component of the multienzyme complex branched-chain alpha-keto acid dehydrogenase, i.e. branched-chain 2-oxo acid dehydrogenase Homo sapiens