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Literature summary extracted from

  • King, R.S.; Duffel, M.W.
    Oxidation-dependent inactivation of aryl sulfotransferase IV by primary N-hydroxy arylamines during in vitro assays (1997), Carcinogenesis, 18, 843-849.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.9
-
 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.9 4-chloro-N-hydroxyaniline causes inhibition under reaction conditions where oxidative degradation occurs Rattus norvegicus
2.8.2.9 N-hydroxy-2-aminofluorene N-OH-2AF, causes inhibition under reaction conditions where oxidative degradation occurs Rattus norvegicus
2.8.2.9 N-hydroxyaniline causes inhibition under reaction conditions where oxidative degradation occurs, activity rapidly decreases to less than 10% of the initial activity Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.9 0.026
-
 4-chloro-N-hydroxyaniline pH 7, 37°C Rattus norvegicus
2.8.2.9 0.23
-
 N-hydroxyaniline pH 7, 37°C Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.8.2.9 33500
-
 x * 33500, SDS-PAGE Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.9 Rattus norvegicus
-
 male
-
2.8.2.9 Rattus norvegicus
-
 Sprague-Dawley
-
2.8.2.9 Rattus norvegicus Sprague-Dawley
-
 Sprague-Dawley
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.9 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.8.2.9 0.104
-
 recombinant enzyme Rattus norvegicus
2.8.2.9 0.8 1 native enzyme Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
2.8.2.9 -70°C, stable for 6 months in sodium acetate buffer, pH 5.5, 0.25 M sucrose, 10% glycerol, 1 mM dithiothreitol at protein concentration of 1 mg/ml Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.9 3'-phosphoadenylylsulfate + 2-naphthol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
-
 ?
2.8.2.9 3'-phosphoadenylylsulfate + 2-naphthol
-
 Rattus norvegicus Sprague-Dawley adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
-
 ?
2.8.2.9 3'-phosphoadenylylsulfate + 4-chloro-N-hydroxyaniline oxidative degradation N-hydroxyaniline causes inhibition Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.9 3'-phosphoadenylylsulfate + 4-chloro-N-hydroxyaniline oxidative degradation N-hydroxyaniline causes inhibition Rattus norvegicus Sprague-Dawley adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.9 3'-phosphoadenylylsulfate + N-hydroxy-2-aminofluorene causes inhibition under reaction conditions where oxidative degradation occurs Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.9 3'-phosphoadenylylsulfate + N-hydroxy-2-aminofluorene causes inhibition under reaction conditions where oxidative degradation occurs Rattus norvegicus Sprague-Dawley adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.9 3'-phosphoadenylylsulfate + N-hydroxyaniline oxidative degradation of N-hydroxyaniline causes inhibition Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.9 3'-phosphoadenylylsulfate + N-hydroxyaniline oxidative degradation of N-hydroxyaniline causes inhibition Rattus norvegicus Sprague-Dawley adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.9 additional information forms sulfuric acid esters from a wide range of phenols, tyrosine carboxyesters, catechols, benzylic alcohols, arylhydroxamic acids and N-hydroxy arylamines. Stereochemical configuration of chiral benzyclic alcohols is an important factor in substrate specificity. One enantiomer may act as substrate, the other as inhibitor Rattus norvegicus ?
-
 ?
2.8.2.9 additional information forms sulfuric acid esters from a wide range of phenols, tyrosine carboxyesters, catechols, benzylic alcohols, arylhydroxamic acids and N-hydroxy arylamines. Stereochemical configuration of chiral benzyclic alcohols is an important factor in substrate specificity. One enantiomer may act as substrate, the other as inhibitor Rattus norvegicus Sprague-Dawley ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.8.2.9 ? x * 33500, SDS-PAGE Rattus norvegicus