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Literature summary extracted from

  • Mori, K.; Yoshida, K.; Fukazawa, H.; Kiso, Y.; Sayama, N.; Kikuchi, K.; Aizawa, Y.; Abe, K.
    Thyroid hormone regulates rat placental type III iodothyronine deiodinase activity by inducing kinetic changes different from those in the same isozyme in rat brain (1995), Endocr. J., 42, 753-760.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.21.99.3 Phospholipids no influence on the kinetic parameters of 5-deiodinase activity of isozyme type III in placenta, but essential for activity Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.21.99.3 Phospholipids no inhibition of placental isozyme type III Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.21.99.3 additional information
-
 additional information kinetics, isozyme type III Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.21.99.3 microsome isozyme type III Rattus norvegicus
-
-
1.21.99.3 mitochondrion isozyme type III Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.21.99.3 additional information Rattus norvegicus placental isozyme type III is only slightly increased in hyperthyroidism, while brain isozyme type III is strongly induced ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.21.99.3 Rattus norvegicus
-
 Sprague-Dawley rats
-
1.21.99.3 Rattus norvegicus
-
 isozyme type III
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.21.99.3 brain isozyme type III Rattus norvegicus
-
1.21.99.3 cerebral cortex isozyme type III Rattus norvegicus
-
1.21.99.3 placenta isozyme type III Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.21.99.3 additional information
-
 activity in hyperthyroid and control rats at different substrate concentrations Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.99.3 3,3',5-triiodo-L-thyronine + AH2 best substrate Rattus norvegicus 3,3'-diiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 3,3',5-triiodo-L-thyronine + AH2 isozyme type III Rattus norvegicus 3,3'-diiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 preferred substrate Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 isozyme type III Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 5-deiodinase activity Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 additional information placental isozyme type III is only slightly increased in hyperthyroidism, while brain isozyme type III is strongly induced Rattus norvegicus ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.21.99.3 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.21.99.3 7.5
-
 assay at Rattus norvegicus