Literature summary extracted from

Wu, J.C.; Carr, S.F.; Jarnagin, K.; Kirsher, S.; Barnett, J.; Chow, J.; Chan, H.W.; Chen, M.S.; Medzihradszky, D.; Yamashiro, D.; et al.
Synthetic HIV-2 protease cleaves the GAG precursor of HIV-1 with the same specificity as HIV-1 protease (1990), Arch. Biochem. Biophys., 277, 306-311.

Application

EC Number	Application	Comment	Organism
3.4.23.47	medicine	potential target for chemotherapy of virus infection and associated diseases, essential for maturation of infectious virions, development of drugs against the protease should be effective against HIV-2	Human immunodeficiency virus 2

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.23.47	additional information	no inhibition with 1,10-phenanthroline and phenylmethylsulfonylfluoride or EDTA	Human immunodeficiency virus 2
3.4.23.47	pepstatin A	-	Human immunodeficiency virus 2

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.4.23.47	GAG precursor protein of HIV-2 + H2O	Human immunodeficiency virus 2	-	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.23.47	Human immunodeficiency virus 2	-	human immunodeficiency virus type 2	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.23.47	GAG precursor protein F16 of HIV-1 + H2O	chemically synthesized aspartyl protease enzyme catalyzes specific processing of the recombinant 43-kDa protein	Human immunodeficiency virus 2	?	-	?
3.4.23.47	GAG precursor protein of HIV-2 + H2O	-	Human immunodeficiency virus 2	?	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)