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Literature summary extracted from

  • Simbulan, C.M.G.; Taki, T.; Tamiya-Koizumi, K.; Suzuki, M.; Savoysky, E.; Shoji, M.; Yoshida, S.
    Sulfate- and sialic acid-containing glycolipids inhibit DNA polymerase alpha activity (1994), Biochim. Biophys. Acta, 1205, 68-74.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.7 cerebroside sulfate ester inhibition of polymerase alpha and gamma Bos taurus
2.7.7.7 glycolipids sulfate- and sialic acid-containing Bos taurus
2.7.7.7 sphingosine polymerase alpha and beta Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.7 deoxynucleoside triphosphate + DNAn Bos taurus
-
 diphosphate + DNAn+1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.7 Bos taurus
-
 polymerase alpha
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Bos taurus diphosphate + DNAn+1
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.7.7 0.0004
-
 cerebroside sulfate ester pH 7.2, 37°C Bos taurus
2.7.7.7 0.006
-
 sphingosine pH 7.2, 37°C Bos taurus