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Literature summary extracted from

  • Clark, N.C.; Olsvik, O.; Swenson, J.M.; Spiegel, C.A.; Tenover, F.C.
    Detection of a streptomycin/spectinomycin adenylyltransferase gene (aadA) in Enterococcus faecalis (1999), Antimicrob. Agents Chemother., 43, 157-160.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.7.7.47 medicine streptomycin continues to be an important drug for synergistic therapy of serious enterococcal infections Enterococcus faecalis

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.47 aadA resistence gene transferred vi filter mating from Enterococcus faecalis W4770 to Enterococcus faecalis JH2-2, PCR amplified aadA gene cloned into vector pCRII and transformed into Escherichia coli DH5-alpha Enterococcus faecalis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.47 ATP + streptomycin Enterococcus faecalis
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.47 Enterococcus faecalis Q71UU1 W4770, aadA nucleotide sequence
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.47 ATP + spectinomycin
-
 Enterococcus faecalis diphosphate + 9-adenylylspectinomycin
-
 ?
2.7.7.47 ATP + streptomycin
-
 Enterococcus faecalis diphosphate + 3''-adenylylstreptomycin
-
 ?
2.7.7.47 ATP + tetracyclin
-
 Enterococcus faecalis diphosphate + 3''adenylyltetracyclin
-
 ?
2.7.7.47 additional information no resistance to ampicillin, chloramphenicol, ciprofloxacin, gentamicin, imipenem, penicillin, quinupristin/dalfopristin, rifampin, teicoplanin, and vancomycin mediated Enterococcus faecalis ?
-
 ?