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Literature summary extracted from

  • Saito, S.; Goto, K.; Tonosaki, A.; Kondo, H.
    Gene cloning and characterization of CDP-diacylglycerol synthase from rat brain (1997), J. Biol. Chem., 272, 9503-9509.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.41
-
 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.41 phosphatidylinositol 4,5-bisphosphate strong Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.41 0.102
-
 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphate pH 7.5, 30°C Rattus norvegicus
2.7.7.41 0.114
-
 1,2-dioleoyl-sn-glycerol 3-phosphate pH 7.5, 30°C Rattus norvegicus
2.7.7.41 0.138
-
 phosphatidic acid pH 7.5, 30°C Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.41 membrane the enzyme is mainly localized in close association with the membrane of the endoplasmic reticulum of the transfected cells. Several possible membrane-spanning regions Rattus norvegicus 16020
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.41 Rattus norvegicus O35052
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.41 brain
-
 Rattus norvegicus
-
2.7.7.41 cerebellar Purkinje cell
-
 Rattus norvegicus
-
2.7.7.41 photoreceptor inner segment of Rattus norvegicus
-
2.7.7.41 pineal gland
-
 Rattus norvegicus
-
2.7.7.41 spermatid
-
 Rattus norvegicus
-
2.7.7.41 spermatocyte postmitotic Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.41 CTP + 1,2-dioleoyl-sn-glycerol 3-phosphate
-
 Rattus norvegicus diphosphate + CDP-1,2-dioleoylglycerol
-
 ?
2.7.7.41 CTP + 1-stearoyl-2-arachidonoyl phosphatidic acid
-
 Rattus norvegicus diphosphate + CDP-1-stearoyl-2-arachidonoylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate the enzyme prefers 1-stearoyl-2-arachidonoyl phosphatidic acid as substrate. Little or no activity is detected towards phosphatidic acids containing saturated fatty acyl groups in both the sn-1 and sn-2 positions Rattus norvegicus diphosphate + CDPdiacylglycerol
-
 ?