BRENDA - Enzyme Database

The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content

Lykidis, A.; Jackson, P.; Rock, C.O.; Jackowski, S.; J. Biol. Chem. 272, 33402-33409 (1997)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
2.7.7.41
expression in COS cells
Homo sapiens
2.7.8.11
yeast cDNA S45885 used to search, pis1 cDNA cloned and expressed in COS-7 cells
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.7.41
CTP + phosphatidate
Homo sapiens
the level of CDP-diacylglycerol synthetase 1 is not a critical determinant of cellular phosphatidylinositol content. This argues against a determining role of the activity in the regulation of phosphatidylinositol biosynthesis
diphosphate + CDPdiacylglycerol
-
-
?
2.7.8.11
CDP-diacylglycerol + myo-inositol
Homo sapiens
-
CMP + phosphatidyl-1D-myo-inositol
-
Homo sapiens
r
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.7.41
Homo sapiens
Q92903
-
-
2.7.8.11
Homo sapiens
O14735
human
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.7.41
CTP + phosphatidate
-
643323
Homo sapiens
diphosphate + CDPdiacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
the level of CDP-diacylglycerol synthetase 1 is not a critical determinant of cellular phosphatidylinositol content. This argues against a determining role of the activity in the regulation of phosphatidylinositol biosynthesis
643323
Homo sapiens
diphosphate + CDPdiacylglycerol
-
-
-
?
2.7.8.11
CDP-diacylglycerol + myo-inositol
-
643323
Homo sapiens
CMP + phosphatidyl-1D-myo-inositol
-
643323
Homo sapiens
r
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
2.7.7.41
expression in COS cells
Homo sapiens
2.7.8.11
yeast cDNA S45885 used to search, pis1 cDNA cloned and expressed in COS-7 cells
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.7.41
CTP + phosphatidate
Homo sapiens
the level of CDP-diacylglycerol synthetase 1 is not a critical determinant of cellular phosphatidylinositol content. This argues against a determining role of the activity in the regulation of phosphatidylinositol biosynthesis
diphosphate + CDPdiacylglycerol
-
-
?
2.7.8.11
CDP-diacylglycerol + myo-inositol
Homo sapiens
-
CMP + phosphatidyl-1D-myo-inositol
-
Homo sapiens
r
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.7.41
CTP + phosphatidate
-
643323
Homo sapiens
diphosphate + CDPdiacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
the level of CDP-diacylglycerol synthetase 1 is not a critical determinant of cellular phosphatidylinositol content. This argues against a determining role of the activity in the regulation of phosphatidylinositol biosynthesis
643323
Homo sapiens
diphosphate + CDPdiacylglycerol
-
-
-
?
2.7.8.11
CDP-diacylglycerol + myo-inositol
-
643323
Homo sapiens
CMP + phosphatidyl-1D-myo-inositol
-
643323
Homo sapiens
r