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Literature summary extracted from

  • Deyrup, A.T.; Krishnan, S.; Cockburn, B.N.; Schwartz, N.B.
    Deletion and site-directed mutagenesis of the ATP-binding motif (P-loop) in the bifunctional murine ATP-sulfurylase/adenosine 5'-phosphosulfate kinase enzyme (1998), J. Biol. Chem., 273, 9450-9456.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.7.7.4 C53A mutation has no effect on activity Mus musculus
2.7.7.4 C77A mutation has no effect on activity Mus musculus
2.7.7.4 C84A mutation has no effect on activity Mus musculus
2.7.7.4 G59A significant effect on ATP sulfurylase activity, no effect on adenosine 5'-phosphosulfate kinase activity Mus musculus
2.7.7.4 G62A mutation has no effect on activity Mus musculus
2.7.7.4 G64A diminished adenosine 5'-phosphosulfate kinase activity Mus musculus
2.7.7.4 K65A mutation ablates adenosine 5'-phosphosulfate kinase activity while leaving ATP sulfurylase activity intact Mus musculus
2.7.7.4 K65R mutation ablates adenosine 5'-phosphosulfate kinase activity while leaving ATP sulfurylase activity intact Mus musculus
2.7.7.4 T66A mutation ablates adenosine 5'-phosphosulfate kinase activity while leaving ATP sulfurylase activity intact Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.4 Mus musculus
-
 bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.4 brain
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.4 ATP + sulfate
-
 Mus musculus diphosphate + adenylylsulfate
-
 r

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.7.4 8.8
-
 synthesis of ATP, enzyme form ATPSm and ATPSc Mus musculus