Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Christofori, G.; Keller, W.
    Poly(A) polymerase purified from HeLa cell nuclear extract is required for both cleavage and polyadenylation of pre-mRNA in vitro (1989), Mol. Cell. Biol., 9, 193-203.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.19 nucleus
-
 Homo sapiens 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.7.19 Mg2+ in presence of Mg2+ and a specificity factor required for correct cleavage at the poly(A) site of pre-mRNA Homo sapiens
2.7.7.19 Mn2+ nonspecific adenylation of RNA in presence of Mn2+ Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.7.19 50000 60000 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.19 ATP + RNA Homo sapiens the enzymatic machinery that catalyzes formation of 3'-ends of polyadenylated mRNAs consists of two distinct factors: a poly(A) polymerase and a cleavage/specificity factor required for the correct cleavage at the poly(A) site of pre-mRNA ?
-
 ?
2.7.7.19 ATP + RNA Homo sapiens involved in the 3'-end processing of mRNA ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.19 Homo sapiens
-
 HeLa cells
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.19
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.19 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.19 ATP + RNA primer required Homo sapiens diphosphate + RNA(A)n
-
 ?
2.7.7.19 ATP + RNA enzyme also has cleavage activity Homo sapiens diphosphate + RNA(A)n
-
 ?
2.7.7.19 ATP + RNA the enzymatic machinery that catalyzes formation of 3'-ends of polyadenylated mRNAs consists of two distinct factors: a poly(A) polymerase and a cleavage/specificity factor required for the correct cleavage at the poly(A) site of pre-mRNA Homo sapiens ?
-
 ?
2.7.7.19 ATP + RNA involved in the 3'-end processing of mRNA Homo sapiens ?
-
 ?