Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Abraham, A.K.; Jacob, S.T.
    Hydrolysis of poly (A) to adenine nucleotides by purified poly (A) polymerase (1978), Proc. Natl. Acad. Sci. USA, 75, 2085-2087.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.19 ADP inhibits hydrolytic reaction Rattus norvegicus
2.7.7.19 AMP inhibits hydrolytic reaction Rattus norvegicus
2.7.7.19 ATP inhibits hydrolytic reaction Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.7.19 Mg2+ more active in presence of Mn2+ than Mg2+ Rattus norvegicus
2.7.7.19 Mn2+ more active in presence of Mn2+ than Mg2+ Rattus norvegicus
2.7.7.19 Mn2+ optimal concentration: 0.50-0.75 mM Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.19 ATP + RNA Rattus norvegicus synthetic and hydrolytic activities are functions of the same molecule, the level of adenine nucleotides regulates synthesis and degradation of poly(A), the hydrolytic reaction is responsible for poly(A) shortening or turnover, poly(A) itself is a storage form of adenine nucleotides ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.19 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.19 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.19 ATP + RNA primer required Rattus norvegicus diphosphate + RNA(A)n AMP is the predominant product of the hydrolysis, ADP and ATP are also formed r
2.7.7.19 ATP + RNA enzyme also catalyzes hydrolysis of poly(A) Rattus norvegicus diphosphate + RNA(A)n AMP is the predominant product of the hydrolysis, ADP and ATP are also formed r
2.7.7.19 ATP + RNA does not degrade poly(A) associated with poly(A)*poly(U) helical structure Rattus norvegicus diphosphate + RNA(A)n AMP is the predominant product of the hydrolysis, ADP and ATP are also formed r
2.7.7.19 ATP + RNA synthetic and hydrolytic activities are functions of the same molecule, the level of adenine nucleotides regulates synthesis and degradation of poly(A), the hydrolytic reaction is responsible for poly(A) shortening or turnover, poly(A) itself is a storage form of adenine nucleotides Rattus norvegicus ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.7.19 6.4 8 in presence of Mn2+ Rattus norvegicus