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Literature summary extracted from

  • Mayes, J.S.; Hansen, R.G.
    Galactose 1-phosphate uridyl transferase (1966), Methods Enzymol., 9, 708-713.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.7.12 2-mercaptoethanol
-
 Bos taurus
2.7.7.12 cysteine activation Bos taurus
2.7.7.12 glutathione
-
 Bos taurus

General Stability

EC Number General Stability Organism
2.7.7.12 SH-reagents stabilize Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.12 Ca2+
-
 Bos taurus
2.7.7.12 Cu2+
-
 Bos taurus
2.7.7.12 Mg2+
-
 Bos taurus
2.7.7.12 Mn2+
-
 Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.7.12 additional information no requirement for divalent cations Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.12 UDP-glucose + alpha-D-galactose 1-phosphate Homo sapiens important step in galactose metabolism alpha-D-glucose 1-phosphate + UDP-galactose
-
 r
2.7.7.12 UDP-glucose + alpha-D-galactose 1-phosphate Bos taurus important step in galactose metabolism alpha-D-glucose 1-phosphate + UDP-galactose
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.12 Bos taurus
-
 calf
-
2.7.7.12 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.12 about 500fold Homo sapiens
2.7.7.12 about 500fold Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.12 erythrocyte
-
 Homo sapiens
-
2.7.7.12 liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.7.12 0.058
-
 purified enzyme Homo sapiens
2.7.7.12 12.4
-
 purified enzyme Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.12 CDP-glucose + alpha-D-galactose 1-phosphate low activity Bos taurus alpha-D-glucose 1-phosphate + CDP-galactose
-
 ?
2.7.7.12 additional information
-
 Homo sapiens ?
-
 ?
2.7.7.12 additional information no activity with fructose 1-phosphate and galactose 6-phosphate Bos taurus ?
-
 ?
2.7.7.12 additional information no activity with ADP-glucose or GDP-glucose Bos taurus ?
-
 ?
2.7.7.12 additional information no activity with xylose 1-phosphate, and IDP-glucose Bos taurus ?
-
 ?
2.7.7.12 TDP-glucose + alpha-D-galactose 1-phosphate 8.7% activity compared to UDP-glucose Bos taurus alpha-D-glucose 1-phosphate + TDP-galactose
-
 r
2.7.7.12 UDP-glucose + alpha-D-galactose 1-phosphate
-
 Homo sapiens alpha-D-glucose 1-phosphate + UDP-galactose
-
 r
2.7.7.12 UDP-glucose + alpha-D-galactose 1-phosphate
-
 Bos taurus alpha-D-glucose 1-phosphate + UDP-galactose
-
 r
2.7.7.12 UDP-glucose + alpha-D-galactose 1-phosphate important step in galactose metabolism Homo sapiens alpha-D-glucose 1-phosphate + UDP-galactose
-
 r
2.7.7.12 UDP-glucose + alpha-D-galactose 1-phosphate important step in galactose metabolism Bos taurus alpha-D-glucose 1-phosphate + UDP-galactose
-
 r

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
2.7.7.12 6
-
 t1/2: 18 h, sulfhydryl compounds stabilize Bos taurus
2.7.7.12 7 8 fairly stable Bos taurus