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Literature summary extracted from

  • Sestini, S.; Ricci, C.; Micheli, V.; Pompucci, G.
    Nicotinamide mononucleotide adenylyltransferase activity in human erythrocytes (1993), Arch. Biochem. Biophys., 302, 206-211.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.1 additional information no inhibition by nicotinic acid and nicotinamide Homo sapiens
2.7.7.1 nicotinamide ribonucleotide strong, nicotinate ribonucleotide as substrate Homo sapiens
2.7.7.1 nicotinate ribonucleotide nicotinamide ribonucleotide as substrate Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.1 0.147 0.2 nicotinamide ribonucleotide 37°C, pH 7.6 Homo sapiens
2.7.7.1 0.5 0.52 ATP 37°C, pH 7.6 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.1 cytoplasm
-
 Homo sapiens 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.7.1 Mg2+ requirement Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.1 ATP + nicotinamide ribonucleotide Homo sapiens
-
 diphosphate + NAD+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.1 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.1 partial Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.1 erythrocyte
-
 Homo sapiens
-

Storage Stability

EC Number Storage Stability Organism
2.7.7.1 -20°C, in stroma-free lysate: 30% loss of activity within 2-3 days, in washed erythrocytes: up to 1 month Homo sapiens
2.7.7.1 0-3°C, E. coli enzyme: 31 days stable, yeast enzyme: 22% loss of activity within 31 days Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.1 ATP + nicotinamide ribonucleotide
-
 Homo sapiens diphosphate + NAD+
-
 r
2.7.7.1 ATP + nicotinamide ribonucleotide i.e. NMN or nicotinamide mononucleotide Homo sapiens diphosphate + NAD+
-
 r
2.7.7.1 ATP + nicotinate ribonucleotide i.e. nicotinate mononucleotide Homo sapiens diphosphate + nicotinic acid-adenine dinucleotide
-
 r

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.7.1 37
-
 assay at Homo sapiens