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Literature summary extracted from

  • Sly, W.S.; Stadtman, E.R.
    Formate metabolsim. II Enzymatic synthesis of formyl phosphate and formal coenzyme A in Clostridium cylindrosporum (1963), J. Biol. Chem., 238, 2639-2647.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.2.6 p-mercuribenzoate formate kinase I and II Clostridium cylindrosporum
2.7.2.6 p-mercuriphenylsulfonic acid
-
 Clostridium cylindrosporum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.2.6 400
-
 formate formate kinase I, ATP + formate + hydroxylamine Clostridium cylindrosporum

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.2.6 Mg2+ formate kinase I: activates, formate kinase II: 80% as effective as Mn2+ in activation, Km: 2.5 mM Clostridium cylindrosporum
2.7.2.6 Mn2+ formate kinase I: can partially replace Mg2+ in activation, formate kinase II: activates, Km: 0.5 mM Clostridium cylindrosporum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.2.6 ATP + formate Clostridium cylindrosporum the product formyl phosphate serves as formyl donor for the synthesis of formyl coenzyme A in a reaction catalyzed by phosphate acetyltransferase ADP + formyl phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.2.6 Clostridium cylindrosporum
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.2.6 partial, formate kinase I and formate kinase II Clostridium cylindrosporum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.2.6 ATP + acetate formate kinase II Clostridium cylindrosporum ADP + acetyl phosphate
-
 ?
2.7.2.6 ATP + formate formate kinase I: reaction is not easily, if at all, reversible, reaction catalyzed by formate kinase II is freely reversible Clostridium cylindrosporum ADP + formyl phosphate
-
 r
2.7.2.6 ATP + formate the product formyl phosphate serves as formyl donor for the synthesis of formyl coenzyme A in a reaction catalyzed by phosphate acetyltransferase Clostridium cylindrosporum ADP + formyl phosphate
-
 ?
2.7.2.6 ATP + propionate formate kinase II Clostridium cylindrosporum ADP + propionyl phosphate
-
 ?
2.7.2.6 CTP + formate formate kinase I: less than 5% as effective as ATP, formate kinase II: 30% as effective as ATP Clostridium cylindrosporum CDP + formyl phosphate
-
 r
2.7.2.6 GTP + formate formate kinase I: 20% as effective as ATP, formate kinase II: nearly as effective as ATP Clostridium cylindrosporum GDP + formyl phosphate
-
 r
2.7.2.6 ITP + formate formate kinase I: less than 5% as effective as ATP, formate kinase II: 60% as effective as ATP Clostridium cylindrosporum IDP + formyl phosphate
-
 r
2.7.2.6 UTP + formate formate kinase I: less than 5% as effective as ATP, formate kinase II: 50% as effective as ATP Clostridium cylindrosporum UDP + formyl phosphate
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.7.2.6 More formate kinase II may be identical with acetate kinase Clostridium cylindrosporum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.2.6 6.8 6.9 formate kinase I Clostridium cylindrosporum
2.7.2.6 7.2
-
 formate kinase II Clostridium cylindrosporum