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Literature summary extracted from

  • Jetten, M.S.M.; Follettie, M.T.; Sinskey, A.J.
    Effect of different levels of aspartokinase on the lysine production by Corynebacterium lactofermentum (1995), Appl. Microbiol. Biotechnol., 43, 76-82.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.2.4
-
 Corynebacterium flavescens
2.7.2.4 ask-asd operon cloned Corynebacterium glutamicum

Protein Variants

EC Number Protein Variants Comment Organism
2.7.2.4 G345D mutation in the beta-subunit of the ask gene Corynebacterium flavescens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.2.4 additional information completely resistant to inhibition by mixtures of L-lysine and threonine Corynebacterium glutamicum

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.2.4 18000
-
 1 * 18000 + 1 * 45000, Western blot immunoanalysis Corynebacterium flavescens
2.7.2.4 45000
-
 1 * 18000 + 1 * 45000, Western blot immunoanalysis Corynebacterium flavescens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.2.4 ATP + L-aspartate Corynebacterium glutamicum
-
 ADP + 4-phospho-L-aspartate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.2.4 Corynebacterium flavescens
-
 N13
-
2.7.2.4 Corynebacterium flavescens N13
-
 N13
-
2.7.2.4 Corynebacterium glutamicum Q46133 ATCC 21799, nucleotide sequence encoding the beta-subunit
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.2.4 0.034
-
-
 Corynebacterium glutamicum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.2.4 ATP + L-aspartate
-
 Corynebacterium glutamicum ADP + 4-phospho-L-aspartate
-
 r
2.7.2.4 additional information no isoenzymes Corynebacterium glutamicum ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.2.4 heterodimer 1 * 18000 + 1 * 45000, Western blot immunoanalysis Corynebacterium flavescens