Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Lay, A.J.; Jiang, X.M.; Kisker, O.; Flynn, E.; Underwood, A.; Condron, R.; Hogg, P.J.
    Phosphoglycerate kinase acts in tumor angiogenesis as a disulfide reductase (2000), Nature, 408, 869-873.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.2.3 DNA sequence determination and expression in Escherichia coli BL21(DE3) Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.2.3 additional information Homo sapiens enzyme acts as a disulfide reductase, e.g. plasmin reductase, in tumour angiogenesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.2.3 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.2.3 recombinant enzyme from Escherichia coli Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.2.3 AsPC-1 cell pancreatic carcinoma cell line, low amount of enzyme compared to HT-1080 cells Homo sapiens
-
2.7.2.3 BT-20 cell breast carcinoma cell line, reduced amount of enzyme compared to HT-1080 cells Homo sapiens
-
2.7.2.3 BxPC-3 cell pancreatic carcinoma cell line, low amount of enzyme compared to HT-1080 cells Homo sapiens
-
2.7.2.3 HS-766T cell pancreatic carcinoma cell line, the same amount of enzyme compared to HT-1080 cells Homo sapiens
-
2.7.2.3 HS-766T cell pancreatic carcinoma cell line, reduced amount of enzyme compared to HT-1080 cells Homo sapiens
-
2.7.2.3 HT-1080 cell
-
 Homo sapiens
-
2.7.2.3 Lim1215 cell colon carcinoma cell line, nearly the same amount of enzyme compared to HT-1080 cells Homo sapiens
-
2.7.2.3 Lim1863 cell colon carcinoma cell line, increased amount of enzyme compared to HT-1080 cells Homo sapiens
-
2.7.2.3 Lim2412 cell colon carcinoma cell line, increased amount of enzyme compared to HT-1080 cells Homo sapiens
-
2.7.2.3 MCF-7 cell breast carcinoma cell line, the same amount of enzyme compared to HT-1080 cells Homo sapiens
-
2.7.2.3 MDA-MB-231 cell breast carcinoma cell line, low amount of enzyme compared to HT-1080 cells Homo sapiens
-
2.7.2.3 SU.86.86 cell pancreatic carcinoma cell line, very high amount of enzyme compared to HT-1080 cells Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.2.3 ATP + 3-phospho-D-glycerate
-
 Homo sapiens ADP + 1,3-diphosphoglycerate
-
 r
2.7.2.3 additional information enzyme acts as a disulfide reductase, e.g. plasmin reductase, in tumour angiogenesis Homo sapiens ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.2.3 ADP
-
 Homo sapiens
2.7.2.3 ATP required as phosphate donor Homo sapiens