Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Ravindran, S.; Radke, G.A.; Guest, J.R.; Roche, T.E.
    Lipoyl domain-based mechanism for the integrated feedback control of the pyruvate dehydrogenase complex by enhancement of pyruvate dehydrogenase kinase activity (1996), J. Biol. Chem., 271, 653-662.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.2 acetyl-CoA involved in the regulation of enzyme activity regulating pyruvate dehydrogenase complex Bos taurus
2.7.11.2 acetyl-CoA high stimulation through acetylation of the transacetylase-catalyzing inner core portion of the dihydrolipoyl acetyltransferase Bos taurus
2.7.11.2 dihydrolipoyl transacetylase involved in the regulation of enzyme activity regulating pyruvate dehydrogenase complex Bos taurus
2.7.11.2 dihydrolipoyl transacetylase binding and activation mechanism Bos taurus
2.7.11.2 NADH involved in the regulation of enzyme activity regulating pyruvate dehydrogenase complex Bos taurus
2.7.11.2 pyruvate at low concentration, with the thiamine diphosphate containing pyruvate dehydrogenase complex, stimulation mechanism Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.2 ATP + [pyruvate dehydrogenase (lipoamide)] Bos taurus catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.2 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.2 kidney
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.2 ATP + [pyruvate dehydrogenase (lipoamide)] incorporates gamma-phosphate from ATP into E1-component of pyruvate dehydrogenase-complex alpha-subunit Bos taurus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir
2.7.11.2 ATP + [pyruvate dehydrogenase (lipoamide)] catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 Bos taurus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.2 ATP dependent on Bos taurus