BRENDA - Enzyme Database show

Nucleotide specificity of human deoxycytidine kinase

Shewach, D.S.; Reynolds, K.K.; Hertel, L.; Mol. Pharmacol. 42, 518-524 (1992)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.1.74
dCTP
no inhibition at physiological concentrations
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.1.74
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.74
leukemia cell
cell line MOLT-4; leukemic T-lymphoblasts
Homo sapiens
-
2.7.1.74
MOLT-4 cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
NTP + 2',2'-difluoro-2'-deoxycytidine
best acceptor substrate, best phosphate donors: UTP or NTP-mixture, better than ATP
641946
Homo sapiens
NDP + 2',2'-difluoro-2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.74
NTP + 9-beta-D-arabinofuranosyl-2-fluoroadenine
-
641946
Homo sapiens
NDP + 9-beta-D-arabinofuranosyl-2-fluoroadenine 5'-phosphate
-
-
-
?
2.7.1.74
NTP + cytosine arabinoside
D-isomer
641946
Homo sapiens
NDP + cytosine arabinoside 5'-monophosphate
-
-
-
?
2.7.1.74
NTP + cytosine arabinoside
best phosphate donors: UTP or NTP-mixture, even better than ATP
641946
Homo sapiens
NDP + cytosine arabinoside 5'-monophosphate
-
-
-
?
2.7.1.74
NTP + deoxycytidine
enzyme shows little specificity towards phosphate donor
641946
Homo sapiens
NDP + dCMP
-
-
-
?
2.7.1.74
UTP + 2'-deoxycytidine
as good as CTP, GTP or dATP
641946
Homo sapiens
UDP + 2'-deoxy-CMP
-
-
-
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.1.74
dCTP
no inhibition at physiological concentrations
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.74
leukemia cell
cell line MOLT-4; leukemic T-lymphoblasts
Homo sapiens
-
2.7.1.74
MOLT-4 cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
NTP + 2',2'-difluoro-2'-deoxycytidine
best acceptor substrate, best phosphate donors: UTP or NTP-mixture, better than ATP
641946
Homo sapiens
NDP + 2',2'-difluoro-2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.74
NTP + 9-beta-D-arabinofuranosyl-2-fluoroadenine
-
641946
Homo sapiens
NDP + 9-beta-D-arabinofuranosyl-2-fluoroadenine 5'-phosphate
-
-
-
?
2.7.1.74
NTP + cytosine arabinoside
D-isomer
641946
Homo sapiens
NDP + cytosine arabinoside 5'-monophosphate
-
-
-
?
2.7.1.74
NTP + cytosine arabinoside
best phosphate donors: UTP or NTP-mixture, even better than ATP
641946
Homo sapiens
NDP + cytosine arabinoside 5'-monophosphate
-
-
-
?
2.7.1.74
NTP + deoxycytidine
enzyme shows little specificity towards phosphate donor
641946
Homo sapiens
NDP + dCMP
-
-
-
?
2.7.1.74
UTP + 2'-deoxycytidine
as good as CTP, GTP or dATP
641946
Homo sapiens
UDP + 2'-deoxy-CMP
-
-
-
?