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Literature summary extracted from

  • Urumow, T.; Wieland, O.H.
    Purification and partial characterization of phosphatidylinositol-4-phosphate kinase from rat liver plasma membranes. Further evidence for a stimulatory G-protein (1990), Biochim. Biophys. Acta, 1052, 152-158.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.68 ADP
-
 Rattus norvegicus
2.7.1.68 quercetin
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.68 0.01
-
 1-phosphatidyl-1D-myo-inositol 4-phosphate pH 7.5, 25°C Rattus norvegicus
2.7.1.68 0.065
-
 ATP pH 7.5, 25°C Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.68 plasma membrane
-
 Rattus norvegicus 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.68 Ca2+ activates to a smaller extent than Mg2+ Rattus norvegicus
2.7.1.68 Mg2+ required, Km: 10 mM Rattus norvegicus
2.7.1.68 Mn2+ activates to a smaller extent than Mg2+ Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Rattus norvegicus the enzyme from liver membrane is possible regulated by a G-protein ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.68 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.68
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.68 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.68 1.021
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate the enzyme from liver membrane is possible regulated by a G-protein Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.68 0.035
-
 quercetin pH 7.5, 25°C Rattus norvegicus