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Literature summary extracted from

  • Verghese, M.; Fernandis, A.Z.; Subrahmanyam, G.
    Purification and characterization of a type II phosphatidylinositol 4-kinase from rat spleen and comparison with a PtdIns 4-kinase from lymphocytes (1999), Indian J. Biochem. Biophys., 36, 1-9.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.67 spermine stimulates Rattus norvegicus
2.7.1.67 Triton X-100 stimulates Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.67 adenosine
-
 Rattus norvegicus
2.7.1.67 Ca2+
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.67 0.022
-
 phosphatidylinositol
-
 Rattus norvegicus
2.7.1.67 0.05
-
 ATP
-
 Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.67 Mg2+ 10-12 mM, effective divalent cation activator Rattus norvegicus
2.7.1.67 Mn2+ can not substitute for Mg2+ in activation Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.67 55000
-
 x * 55000, SDS-PAGE Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.67 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.67 type II enzyme Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.67 lymphocyte spleen Rattus norvegicus
-
2.7.1.67 spleen
-
 Rattus norvegicus
-
2.7.1.67 spleen lymphocyte Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.67 0.05994
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol
-
 Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.67 ? x * 55000, SDS-PAGE Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.67 0.018
-
 adenosine
-
 Rattus norvegicus