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Literature summary extracted from

  • Zhao, X.; Varnai, P.; Tuymetova, G.; Balla, A.; Toth, Z.E.; Oker-Blom, C.; Roder, J.; Jeromin, A.; Balla, T.
    Interaction of neuronal calcium sensor-1 (NCS-1) with phosphatidylinositol 4-kinase b stimulates lipid kinase activity and affects membrane trafficking in COS-7 cells (2001), J. Biol. Chem., 276, 40183-40189.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.67
-
 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.67 adenosine
-
 Bos taurus
2.7.1.67 ATP
-
 Bos taurus
2.7.1.67 Wortmannin type II enzyme is inhibited by low concentrations, type III enzyme requires mM concentrations for inhibition Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.67 chromaffin granule
-
 Bos taurus 42583
-
2.7.1.67 membrane
-
 Rattus norvegicus 16020
-
2.7.1.67 membrane type II enzyme is almost exclusively found in membrane fraction Bos taurus 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.67 54305
-
 x * 54305, calculation from nucleotide sequence Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol Rattus norvegicus
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol Bos taurus phosphorylation of phosphatidylinositol at the D-4 position is an essential step in the biosynthesis of phosphatidylinositolpolyphosphates ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.67 Bos taurus
-
-
-
2.7.1.67 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.67 partial Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.67 adrenal gland PI4KII and PI4KIII Bos taurus
-
2.7.1.67 brain
-
 Rattus norvegicus
-
2.7.1.67 brain
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol
-
 Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol
-
 Bos taurus ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol phosphorylation of phosphatidylinositol at the D-4 position is an essential step in the biosynthesis of phosphatidylinositolpolyphosphates Bos taurus ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.67 ?
-
 Rattus norvegicus
2.7.1.67 ? x * 54305, calculation from nucleotide sequence Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.67 0.045
-
 adenosine type II enzyme Bos taurus
2.7.1.67 0.088
-
 ATP type II enzyme Bos taurus